Adenosine
Generic Name: adenosine
Brand Names:
Adenosine
Adenosine is an endogenous nucleoside occurring in all cells of the body, supplied as a sterile solution containing 3 mg adenosine per mL for intravenous use. It is a prescription cardiac medication.
Overview
Adenosine is an endogenous nucleoside occurring in all cells of the body, supplied as a sterile solution containing 3 mg adenosine per mL for intravenous use. It is a prescription cardiac medication.
Uses
Conversion to normal sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with Wolff-Parkinson-White Syndrome. Does not convert atrial flutter, fibrillation, or ventricular tachycardia.
Dosage
Adults: Initial 6 mg rapid IV bolus over 1-2 seconds; if no response in 1-2 minutes, give 12 mg rapid IV bolus. Pediatric (under 50 kg): 0.05-0.1 mg/kg, maximum 0.3 mg/kg. Must be given as rapid peripheral IV bolus followed by saline flush.
Side Effects
Most common adverse reactions include facial flushing (18%), shortness of breath (12%), chest pressure (7%), nausea (3%), and headache (2%). Serious events may include ventricular fibrillation, asystole, and seizures.
Interactions
Methylxanthines such as caffeine and theophylline antagonize the effects of adenosine. Dipyridamole potentiates the effects. Use caution with digoxin and verapamil.
Warnings
Risk of heart block. Potential ventricular fibrillation when used with digoxin or verapamil. May cause bronchoconstriction in asthmatic patients. Contraindicated in second or third-degree AV block without a pacemaker, sick sinus syndrome, and symptomatic bradycardia.
Pregnancy
No adequate animal or human studies available. Adenosine is a naturally occurring substance. Use only if clearly needed.
Storage
Store at 20-25 degrees C. Do not freeze or refrigerate. Preserve solution clarity.
Frequently Asked Questions
What is Adenosine used for?▼
Conversion to normal sinus rhythm of paroxysmal supraventricular tachycardia (PSVT), including that associated with Wolff-Parkinson-White Syndrome. Does not convert atrial flutter, fibrillation, or ventricular tachycardia.
What are the side effects of Adenosine?▼
Most common adverse reactions include facial flushing (18%), shortness of breath (12%), chest pressure (7%), nausea (3%), and headache (2%). Serious events may include ventricular fibrillation, asystole, and seizures.
Can I take Adenosine during pregnancy?▼
No adequate animal or human studies available. Adenosine is a naturally occurring substance. Use only if clearly needed.
What are the important warnings for Adenosine?▼
Risk of heart block. Potential ventricular fibrillation when used with digoxin or verapamil. May cause bronchoconstriction in asthmatic patients. Contraindicated in second or third-degree AV block without a pacemaker, sick sinus syndrome, and symptomatic bradycardia.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.