Alprazolam
Generic Name: alprazolam
Brand Names:
Alprazolam
Alprazolam is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. Available as tablets in 0.25 mg, 0.5 mg, 1 mg, or 2 mg strengths.
Overview
Alprazolam is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. Available as tablets in 0.25 mg, 0.5 mg, 1 mg, or 2 mg strengths.
Uses
Indicated for acute treatment of generalized anxiety disorder (GAD) in adults and treatment of panic disorder with or without agoraphobia in adults.
Dosage
For GAD: start 0.25-0.5 mg three times daily, increase every 3-4 days to maximum 4 mg daily in divided doses. For Panic Disorder: start 0.5 mg three times daily, increase every 3-4 days by no more than 1 mg per day. When discontinuing, decrease dosage by no more than 0.5 mg every 3 days.
Side Effects
Most common adverse reactions include drowsiness, light-headedness, dizziness, and impaired coordination. Other reactions include dry mouth, hypotension, memory impairment, irritability, and dysarthria. Discontinuation-emergent symptoms include insomnia, anxiety, muscle twitching, and gastrointestinal effects.
Interactions
Strong CYP3A inhibitors (except ritonavir) are contraindicated. Opioids increase respiratory depression risk. CNS depressants produce additive effects. Ketoconazole increases alprazolam concentrations 3.98-fold. Carbamazepine may decrease alprazolam levels.
Warnings
Concomitant use with opioids may cause profound sedation, respiratory depression, coma, and death. Risk of abuse, misuse, and addiction which can lead to overdose or death. Abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions that can be life-threatening.
Pregnancy
Neonates born to mothers using benzodiazepines late in pregnancy may experience sedation and withdrawal symptoms. Monitor neonates for signs of sedation, respiratory depression, hypotonia, and feeding problems.
Storage
Store at 20° to 25°C (68° to 77°F). Keep out of reach of children.
Frequently Asked Questions
What is Alprazolam used for?▼
Indicated for acute treatment of generalized anxiety disorder (GAD) in adults and treatment of panic disorder with or without agoraphobia in adults.
What are the side effects of Alprazolam?▼
Most common adverse reactions include drowsiness, light-headedness, dizziness, and impaired coordination. Other reactions include dry mouth, hypotension, memory impairment, irritability, and dysarthria. Discontinuation-emergent symptoms include insomnia, anxiety, muscle twitching, and gastrointestinal effects.
Can I take Alprazolam during pregnancy?▼
Neonates born to mothers using benzodiazepines late in pregnancy may experience sedation and withdrawal symptoms. Monitor neonates for signs of sedation, respiratory depression, hypotonia, and feeding problems.
What are the important warnings for Alprazolam?▼
Concomitant use with opioids may cause profound sedation, respiratory depression, coma, and death. Risk of abuse, misuse, and addiction which can lead to overdose or death. Abrupt discontinuation or rapid dosage reduction may precipitate acute withdrawal reactions that can be life-threatening.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.