Amitriptyline Hydrochloride
Generic Name: amitriptyline hydrochloride
Brand Names:
Amitriptyline Hydrochloride
Amitriptyline hydrochloride is a dibenzocycloheptadiene derivative, a white or practically white, odorless, crystalline compound which is freely soluble in water and alcohol. Used as a tricyclic antidepressant.
Overview
Amitriptyline hydrochloride is a dibenzocycloheptadiene derivative, a white or practically white, odorless, crystalline compound which is freely soluble in water and alcohol. Used as a tricyclic antidepressant.
Uses
For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.
Dosage
Initial adult dosage typically ranges from 75-150 mg daily in divided doses or 50-100 mg at bedtime. Hospitalized patients may require 100-200 mg daily. Adolescent and elderly patients should receive lower doses (10 mg three times daily with 20 mg at bedtime).
Side Effects
Includes cardiovascular effects (arrhythmias, hypotension), CNS effects (seizures, hallucinations), anticholinergic effects (urinary retention, constipation), allergic reactions, hematologic effects, gastrointestinal disturbances, and endocrine effects.
Interactions
Interactions with topiramate, CYP2D6 inhibitors, MAOIs, anticholinergic agents, cimetidine, and CNS depressants.
Warnings
BOXED WARNING: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents and young adults. Risk of serotonin syndrome, bipolar disorder screening needed, cardiovascular precautions required. Contraindicated with MAO inhibitors and in patients with prior hypersensitivity.
Pregnancy
Use only if potential benefit to the mother justifies the potential risk to the fetus. Drug crosses placenta; animal studies showed teratogenic effects at high doses.
Storage
Store at 20 to 25 degrees C (68 to 77 degrees F). Protect from light. Dispense in tight, light-resistant container with child-resistant closure.
Frequently Asked Questions
What is Amitriptyline Hydrochloride used for?▼
For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.
What are the side effects of Amitriptyline Hydrochloride?▼
Includes cardiovascular effects (arrhythmias, hypotension), CNS effects (seizures, hallucinations), anticholinergic effects (urinary retention, constipation), allergic reactions, hematologic effects, gastrointestinal disturbances, and endocrine effects.
Can I take Amitriptyline Hydrochloride during pregnancy?▼
Use only if potential benefit to the mother justifies the potential risk to the fetus. Drug crosses placenta; animal studies showed teratogenic effects at high doses.
What are the important warnings for Amitriptyline Hydrochloride?▼
BOXED WARNING: Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents and young adults. Risk of serotonin syndrome, bipolar disorder screening needed, cardiovascular precautions required. Contraindicated with MAO inhibitors and in patients with prior hypersensitivity.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.