Amlodipine Besylate And Benazepril Hydrochloride
Generic Name: amlodipine besylate and benazepril hydrochloride
Brand Names:
Amlodipine Besylate And Benazepril Hydrochloride
Amlodipine besylate and benazepril hydrochloride capsules are a combination antihypertensive available in six strengths (2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40 mg) for oral administration.
Overview
Amlodipine besylate and benazepril hydrochloride capsules are a combination antihypertensive available in six strengths (2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40 mg) for oral administration.
Uses
Indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent.
Dosage
Initial dose is one capsule of 2.5 mg/10 mg once daily. Maximum dose is 10 mg/40 mg once daily. Antihypertensive effect largely attained within 2 weeks.
Side Effects
Most common reasons for discontinuation were cough (3.3%) and edema (2.1%). Other side effects include headache (2.2%), dizziness (1.3%), asthenia, flushing, dry mouth, nausea, and muscle cramps.
Interactions
Interactions with potassium supplements, lithium, NSAIDs, simvastatin (limit to 20 mg daily), mTOR inhibitors, and neprilysin inhibitors.
Warnings
BOXED WARNING: Fetal toxicity. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. Risks include angioedema, hypotension, hyperkalemia. Contraindicated with neprilysin inhibitors and in patients with angioedema history.
Pregnancy
Can cause fetal harm when administered to a pregnant woman. When pregnancy is detected, discontinue as soon as possible.
Storage
Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F). Protect from moisture.
Frequently Asked Questions
What is Amlodipine Besylate And Benazepril Hydrochloride used for?▼
Indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent.
What are the side effects of Amlodipine Besylate And Benazepril Hydrochloride?▼
Most common reasons for discontinuation were cough (3.3%) and edema (2.1%). Other side effects include headache (2.2%), dizziness (1.3%), asthenia, flushing, dry mouth, nausea, and muscle cramps.
Can I take Amlodipine Besylate And Benazepril Hydrochloride during pregnancy?▼
Can cause fetal harm when administered to a pregnant woman. When pregnancy is detected, discontinue as soon as possible.
What are the important warnings for Amlodipine Besylate And Benazepril Hydrochloride?▼
BOXED WARNING: Fetal toxicity. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. Risks include angioedema, hypotension, hyperkalemia. Contraindicated with neprilysin inhibitors and in patients with angioedema history.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.