Amoxicillin And Clavulanate Potassium
Generic Name: amoxicillin and clavulanate potassium
Brand Names:
Amoxicillin And Clavulanate Potassium
Amoxicillin and clavulanate potassium is a combination of amoxicillin, a semisynthetic penicillin-class antibacterial, and clavulanate potassium, a beta-lactamase inhibitor. Available as oral suspension.
Overview
Amoxicillin and clavulanate potassium is a combination of amoxicillin, a semisynthetic penicillin-class antibacterial, and clavulanate potassium, a beta-lactamase inhibitor. Available as oral suspension.
Uses
Indicated for pediatric patients aged 3 months to 12 years with recurrent or persistent acute otitis media due to susceptible organisms including S. pneumoniae, H. influenzae, and M. catarrhalis. Also used for lower respiratory tract infections, sinusitis, skin infections, and urinary tract infections in adults.
Dosage
Pediatric patients aged 3 months to 12 years weighing 40 kg or less: 90 mg/kg/day divided every 12 hours for 10 days. Adults: 500 mg or 875 mg every 8-12 hours depending on severity. Administer at the start of a meal to minimize gastrointestinal intolerance and enhance absorption.
Side Effects
Most frequently reported adverse reactions include diarrhea, vomiting, contact dermatitis (diaper rash), fever, upper respiratory tract infection, and coughing. Serious reactions include anaphylaxis, severe cutaneous adverse reactions, drug-induced enterocolitis syndrome, and C. difficile-associated diarrhea.
Interactions
Probenecid co-administration not recommended as it increases amoxicillin blood levels. Concomitant use with oral anticoagulants may prolong prothrombin time. Allopurinol increases rash incidence. May reduce oral contraceptive efficacy.
Warnings
Serious hypersensitivity reactions including anaphylaxis may occur. Monitor for severe cutaneous adverse reactions and discontinue if rash progresses. Drug-induced enterocolitis syndrome characterized by protracted vomiting has been reported. Hepatic dysfunction and C. difficile-associated diarrhea may develop.
Pregnancy
Available data from epidemiologic studies have not established drug-associated risk of major birth defects or miscarriage. However, prophylactic use in preterm prelabor rupture of membranes was associated with increased neonatal necrotizing enterocolitis risk.
Storage
Store dry powder at 20-25°C (68-77°F). Store reconstituted suspension under refrigeration. Discard unused suspension after 10 days.
Frequently Asked Questions
What is Amoxicillin And Clavulanate Potassium used for?▼
Indicated for pediatric patients aged 3 months to 12 years with recurrent or persistent acute otitis media due to susceptible organisms including S. pneumoniae, H. influenzae, and M. catarrhalis. Also used for lower respiratory tract infections, sinusitis, skin infections, and urinary tract infections in adults.
What are the side effects of Amoxicillin And Clavulanate Potassium?▼
Most frequently reported adverse reactions include diarrhea, vomiting, contact dermatitis (diaper rash), fever, upper respiratory tract infection, and coughing. Serious reactions include anaphylaxis, severe cutaneous adverse reactions, drug-induced enterocolitis syndrome, and C. difficile-associated diarrhea.
Can I take Amoxicillin And Clavulanate Potassium during pregnancy?▼
Available data from epidemiologic studies have not established drug-associated risk of major birth defects or miscarriage. However, prophylactic use in preterm prelabor rupture of membranes was associated with increased neonatal necrotizing enterocolitis risk.
What are the important warnings for Amoxicillin And Clavulanate Potassium?▼
Serious hypersensitivity reactions including anaphylaxis may occur. Monitor for severe cutaneous adverse reactions and discontinue if rash progresses. Drug-induced enterocolitis syndrome characterized by protracted vomiting has been reported. Hepatic dysfunction and C. difficile-associated diarrhea may develop.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.