Baclofen
Generic Name: baclofen
Brand Names:
Baclofen
Baclofen is a muscle relaxant and antispastic agent. It is a white to off-white crystalline powder available as 5 mg, 10 mg, or 20 mg tablets for oral administration.
Overview
Baclofen is a muscle relaxant and antispastic agent. It is a white to off-white crystalline powder available as 5 mg, 10 mg, or 20 mg tablets for oral administration.
Uses
Useful for alleviating signs and symptoms of spasticity from multiple sclerosis, particularly for relief of flexor spasms, pain, clonus, and muscular rigidity. May also have value in patients with spinal cord injuries and other spinal cord diseases. Not indicated for skeletal muscle spasm from rheumatic disorders.
Dosage
Optimal dosage requires individual titration starting at low dose, increasing gradually. Suggested schedule: 5 mg three times daily for 3 days, then 10 mg three times daily for 3 days, then 15 mg three times daily for 3 days, then 20 mg three times daily. Total daily dose should not exceed 80 mg daily (20 mg four times daily).
Side Effects
Most common is transient drowsiness (10-63%). Other common effects include dizziness (5-15%), weakness (5-15%), and fatigue (2-4%). Neuropsychiatric effects include confusion, headache, insomnia, hallucinations, tremor, and ataxia. Cardiovascular: hypotension. Gastrointestinal: nausea, constipation.
Warnings
Neonatal withdrawal symptoms reported in infants of mothers treated with baclofen throughout pregnancy. Hallucinations and seizures can occur on abrupt withdrawal. Use with caution in impaired renal function. Baclofen has not significantly benefited stroke patients.
Pregnancy
Animal studies showed increased omphaloceles in rat fetuses at approximately 13 times maximum human dose. No adequate studies in pregnant women. Use only if benefit clearly justifies potential risk to fetus.
Storage
Store at 20° to 25°C (68° to 77°F) in well-closed container with child-resistant closure.
Frequently Asked Questions
What is Baclofen used for?▼
Useful for alleviating signs and symptoms of spasticity from multiple sclerosis, particularly for relief of flexor spasms, pain, clonus, and muscular rigidity. May also have value in patients with spinal cord injuries and other spinal cord diseases. Not indicated for skeletal muscle spasm from rheumatic disorders.
What are the side effects of Baclofen?▼
Most common is transient drowsiness (10-63%). Other common effects include dizziness (5-15%), weakness (5-15%), and fatigue (2-4%). Neuropsychiatric effects include confusion, headache, insomnia, hallucinations, tremor, and ataxia. Cardiovascular: hypotension. Gastrointestinal: nausea, constipation.
Can I take Baclofen during pregnancy?▼
Animal studies showed increased omphaloceles in rat fetuses at approximately 13 times maximum human dose. No adequate studies in pregnant women. Use only if benefit clearly justifies potential risk to fetus.
What are the important warnings for Baclofen?▼
Neonatal withdrawal symptoms reported in infants of mothers treated with baclofen throughout pregnancy. Hallucinations and seizures can occur on abrupt withdrawal. Use with caution in impaired renal function. Baclofen has not significantly benefited stroke patients.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.