Bendamustine Hydrochloride
Generic Name: bendamustine hydrochloride
Brand Names:
Bendamustine Hydrochloride
Bendamustine hydrochloride is an alkylating agent, a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. It is administered as an intravenous infusion for the treatment of certain cancers.
Overview
Bendamustine hydrochloride is an alkylating agent, a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. It is administered as an intravenous infusion for the treatment of certain cancers.
Uses
Indicated for the treatment of adult patients with indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
Dosage
120 mg/m2 infused intravenously over 60 minutes on Days 1 and 2 of a 21-day cycle, up to 8 cycles.
Side Effects
Most common adverse reactions (15% or greater): lymphopenia, leukopenia, anemia, neutropenia, thrombocytopenia, nausea, fatigue, vomiting, diarrhea, and pyrexia.
Interactions
Consider alternative therapies that are not CYP1A2 inducers or inhibitors during treatment with bendamustine.
Warnings
Risk of myelosuppression, infections, progressive multifocal leukoencephalopathy, anaphylaxis, tumor lysis syndrome, skin reactions including Stevens-Johnson syndrome, hepatotoxicity, secondary malignancies, and embryo-fetal toxicity. Contraindicated in patients with known hypersensitivity to bendamustine.
Pregnancy
Animal studies showed embryo-fetal and/or infant mortality, structural abnormalities, and alterations to growth. Can cause fetal harm when administered to a pregnant woman.
Storage
Store in refrigerator, 2C to 8C (36F to 46F).
Frequently Asked Questions
What is Bendamustine Hydrochloride used for?▼
Indicated for the treatment of adult patients with indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen.
What are the side effects of Bendamustine Hydrochloride?▼
Most common adverse reactions (15% or greater): lymphopenia, leukopenia, anemia, neutropenia, thrombocytopenia, nausea, fatigue, vomiting, diarrhea, and pyrexia.
Can I take Bendamustine Hydrochloride during pregnancy?▼
Animal studies showed embryo-fetal and/or infant mortality, structural abnormalities, and alterations to growth. Can cause fetal harm when administered to a pregnant woman.
What are the important warnings for Bendamustine Hydrochloride?▼
Risk of myelosuppression, infections, progressive multifocal leukoencephalopathy, anaphylaxis, tumor lysis syndrome, skin reactions including Stevens-Johnson syndrome, hepatotoxicity, secondary malignancies, and embryo-fetal toxicity. Contraindicated in patients with known hypersensitivity to bendamustine.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.