Bexarotene
Generic Name: bexarotene
Brand Names:
Bexarotene
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). It is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy.
Overview
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). It is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy.
Uses
Indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy.
Dosage
Recommended initial dose is 300 mg/m2/day as a single oral daily dose with meals. Doses may adjust to 200 mg/m2/day or 100 mg/m2/day based on toxicity. If no response after 8 weeks at initial dose, may escalate to 400 mg/m2/day.
Side Effects
Most common adverse reactions include hyperlipidemia, hypercholesteremia, headache, hypothyroidism, asthenia, leukopenia, rash, nausea, infection, peripheral edema, abdominal pain, and dry skin.
Interactions
Avoid gemfibrozil with bexarotene. Bexarotene may induce CYP3A4, reducing effectiveness of hormonal contraceptives and other drugs.
Warnings
Bexarotene is a member of the retinoid class of drugs that is associated with birth defects in humans and caused birth defects in pregnant rats. Must not be administered to pregnant women. Contraindicated in pregnancy and known hypersensitivity. Major concerns include hyperlipidemia, pancreatitis, hepatotoxicity, hypothyroidism, neutropenia, cataracts, and photosensitivity.
Pregnancy
Bexarotene can cause fetal harm when administered to pregnant females and is contraindicated in pregnancy. Discontinue breastfeeding during treatment due to potential serious adverse reactions in nursing infants.
Storage
Store between 36 to 77 degrees F, avoid high temperatures and humidity, protect from light.
Frequently Asked Questions
What is Bexarotene used for?▼
Indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy.
What are the side effects of Bexarotene?▼
Most common adverse reactions include hyperlipidemia, hypercholesteremia, headache, hypothyroidism, asthenia, leukopenia, rash, nausea, infection, peripheral edema, abdominal pain, and dry skin.
Can I take Bexarotene during pregnancy?▼
Bexarotene can cause fetal harm when administered to pregnant females and is contraindicated in pregnancy. Discontinue breastfeeding during treatment due to potential serious adverse reactions in nursing infants.
What are the important warnings for Bexarotene?▼
Bexarotene is a member of the retinoid class of drugs that is associated with birth defects in humans and caused birth defects in pregnant rats. Must not be administered to pregnant women. Contraindicated in pregnancy and known hypersensitivity. Major concerns include hyperlipidemia, pancreatitis, hepatotoxicity, hypothyroidism, neutropenia, cataracts, and photosensitivity.
Related Medications
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.