Bicalutamide
Generic Name: bicalutamide
Brand Names:
Casodex
Bicalutamide is a non-steroidal androgen receptor inhibitor indicated for use in combination therapy with an LHRH analog for the treatment of Stage D2 metastatic carcinoma of the prostate.
Overview
Bicalutamide is a non-steroidal androgen receptor inhibitor indicated for use in combination therapy with an LHRH analog for the treatment of Stage D2 metastatic carcinoma of the prostate.
Uses
Indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate.
Dosage
The recommended dose is one 50 mg tablet once daily (morning or evening), with or without food, in combination with an LHRH analog.
Side Effects
Adverse reactions occurring in more than 10% of patients include hot flashes, pain (general, back, pelvic and abdominal), asthenia, constipation, infection, nausea, peripheral edema, dyspnea, diarrhea, hematuria, nocturia, and anemia.
Interactions
R-bicalutamide is an inhibitor of CYP 3A4; therefore, caution should be used when bicalutamide is co-administered with CYP 3A4 substrates.
Warnings
Severe hepatic injury and fatal hepatic failure have been observed. Monitor serum transaminase levels prior to starting treatment, at regular intervals for the first four months and periodically thereafter. Contraindicated in women and pregnancy. Bicalutamide can cause fetal harm when administered to a pregnant woman.
Pregnancy
Bicalutamide is contraindicated for use in pregnant women because it can cause fetal harm.
Storage
Store at controlled room temperature, 20 to 25 degrees C (68 to 77 degrees F).
Frequently Asked Questions
What is Bicalutamide used for?▼
Indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate.
What are the side effects of Bicalutamide?▼
Adverse reactions occurring in more than 10% of patients include hot flashes, pain (general, back, pelvic and abdominal), asthenia, constipation, infection, nausea, peripheral edema, dyspnea, diarrhea, hematuria, nocturia, and anemia.
Can I take Bicalutamide during pregnancy?▼
Bicalutamide is contraindicated for use in pregnant women because it can cause fetal harm.
What are the important warnings for Bicalutamide?▼
Severe hepatic injury and fatal hepatic failure have been observed. Monitor serum transaminase levels prior to starting treatment, at regular intervals for the first four months and periodically thereafter. Contraindicated in women and pregnancy. Bicalutamide can cause fetal harm when administered to a pregnant woman.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.