Bivalirudin
Generic Name: bivalirudin
Brand Names:
Bivalirudin
Bivalirudin is a synthetic 20 amino acid peptide that acts as a specific, reversible direct thrombin inhibitor. It is indicated as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI), including patients with heparin-induced thrombocytopenia.
Overview
Bivalirudin is a synthetic 20 amino acid peptide that acts as a specific, reversible direct thrombin inhibitor. It is indicated as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI), including patients with heparin-induced thrombocytopenia.
Uses
Indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI) including patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome.
Dosage
Initial intravenous bolus of 0.75 mg/kg followed by 1.75 mg/kg/h infusion during the procedure. Additional 0.3 mg/kg bolus may be given at 5 minutes post-initial dose if needed based on activated clotting time.
Side Effects
Most common adverse reaction is bleeding. Major bleeding events occurred in 3.7% of patients. Postmarketing reports include fatal bleeding, hypersensitivity reactions, anaphylaxis, and thrombus formation.
Interactions
Coadministration with heparin, warfarin, thrombolytics, or GPIs is associated with increased major bleeding risk compared to non-concomitant use.
Warnings
Bivalirudin increases the risk of bleeding. Increased acute stent thrombosis in STEMI patients. Thrombotic risk with coronary artery brachytherapy. Closely monitor elderly patients. Contraindicated in active major bleeding and hypersensitivity to bivalirudin.
Pregnancy
There are no data available on use of bivalirudin in pregnant women, though animal studies showed no fetal harm at recommended doses.
Storage
Store at controlled room temperature 20 to 25 degrees C (68 to 77 degrees F). Reconstituted material may be stored refrigerated for up to 24 hours.
Frequently Asked Questions
What is Bivalirudin used for?▼
Indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI) including patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome.
What are the side effects of Bivalirudin?▼
Most common adverse reaction is bleeding. Major bleeding events occurred in 3.7% of patients. Postmarketing reports include fatal bleeding, hypersensitivity reactions, anaphylaxis, and thrombus formation.
Can I take Bivalirudin during pregnancy?▼
There are no data available on use of bivalirudin in pregnant women, though animal studies showed no fetal harm at recommended doses.
What are the important warnings for Bivalirudin?▼
Bivalirudin increases the risk of bleeding. Increased acute stent thrombosis in STEMI patients. Thrombotic risk with coronary artery brachytherapy. Closely monitor elderly patients. Contraindicated in active major bleeding and hypersensitivity to bivalirudin.
Related Medications
Chlophedianol Hydrochloride, Pyrilamine Maleate, Pseudoephedrine Hydrochloride
chlophedianol hydrochloride, pyrilamine maleate, pseudoephedrine hydrochloride
Purpose Antitussive Antihistamine Nasal Decongestant
Aethusa Cynapium, Ginkgo Biloba, Kali Phosphoricum, Cerebrum Suis, Hypothalamus Suis, Adenosinum Triphosphoricum Dinatrum, Alumina, Anacardium Orientale, Arsenicum Album, Cortisone Aceticum, Levothyroxinum, Lycopodium Clavatum, Nadidum, Phosphorus, Ubidecarenonum, Zincum Metallicum, Acetylcholine Chloride, Dopamine Hydrochloride, Gaba (gamma-aminobutyric Acid), Histaminum Hydrochloricum, Melatonin, Norepinephrine (bitartrate), Oxytocin, Serotonin (hydrochloride)
aethusa cynapium, ginkgo biloba, kali phosphoricum, cerebrum suis, hypothalamus suis, adenosinum triphosphoricum dinatrum, alumina, anacardium orientale, arsenicum album, cortisone aceticum, levothyroxinum, lycopodium clavatum, nadidum, phosphorus, ubidecarenonum, zincum metallicum, acetylcholine chloride, dopamine hydrochloride, gaba (gamma-aminobutyric acid), histaminum hydrochloricum, melatonin, norepinephrine (bitartrate), oxytocin, serotonin (hydrochloride)
l-Thyroxine [EPC]
PURPOSE: May temporarily relieve poor concentration, forgetfulness, sleeplessness, fatigue, and support emotional balance.** **Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.
Tovorafenib
tovorafenib
Kinase Inhibitor [EPC]
11 DESCRIPTION OJEMDA contains tovorafenib, a kinase inhibitor. Tovorafenib has the molecular formula C 17 H 12 Cl 2 F 3 N 7 O 2 S and a molecular weight of 506.29. The chemical name for tovorafenib is 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide. Tovorafenib has the following chemical structure: It is a white to off-white powder.
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.