Bumetanide

Generic Name: bumetanide

Loop Diuretic [EPC]Over-the-Counter (OTC)

Brand Names:

Bumetanide

Bumetanide is a potent loop diuretic indicated for treating edema linked to congestive heart failure, hepatic and renal disease, including nephrotic syndrome.

Overview

Bumetanide is a potent loop diuretic indicated for treating edema linked to congestive heart failure, hepatic and renal disease, including nephrotic syndrome.

Uses

Indicated for treating edema linked to congestive heart failure, hepatic and renal disease, including nephrotic syndrome. Effective via oral or parenteral routes.

Dosage

Standard initial dose is 0.5 to 1 mg intravenously or intramuscularly over 1 to 2 minutes. Additional doses may be given at 2 to 3 hour intervals, not exceeding 10 mg daily. Dosage should be individualized based on patient response.

Side Effects

Most frequent: muscle cramps (1.1%), dizziness (1.1%), hypotension (0.8%). Lab abnormalities include hyperuricemia, hypochloremia, and hypokalemia.

Interactions

Avoid with aminoglycoside antibiotics (ototoxicity risk), nephrotoxic drugs, lithium, probenecid, and indomethacin.

Warnings

Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to profound diuresis with water and electrolyte depletion. Contraindicated in anuria, hepatic coma, severe electrolyte depletion, and hypersensitivity to bumetanide. Risk of ototoxicity and sulfonamide cross-reactivity.

Pregnancy

No adequate controlled studies in pregnant women. Use only if potential benefit justifies fetal risk.

Storage

Store at 20-25 degrees C (68-77 degrees F), protected from light.

Frequently Asked Questions

What is Bumetanide used for?

Indicated for treating edema linked to congestive heart failure, hepatic and renal disease, including nephrotic syndrome. Effective via oral or parenteral routes.

What are the side effects of Bumetanide?

Most frequent: muscle cramps (1.1%), dizziness (1.1%), hypotension (0.8%). Lab abnormalities include hyperuricemia, hypochloremia, and hypokalemia.

Can I take Bumetanide during pregnancy?

No adequate controlled studies in pregnant women. Use only if potential benefit justifies fetal risk.

What are the important warnings for Bumetanide?

Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to profound diuresis with water and electrolyte depletion. Contraindicated in anuria, hepatic coma, severe electrolyte depletion, and hypersensitivity to bumetanide. Risk of ototoxicity and sulfonamide cross-reactivity.

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Medical Disclaimer

This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.