Bupivacaine Hydrochloride
Generic Name: bupivacaine hydrochloride
Brand Names:
Bupivacaine Hydrochloride
Bupivacaine hydrochloride injection is an amide-type local anesthetic indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and obstetrical procedures.
Overview
Bupivacaine hydrochloride injection is an amide-type local anesthetic indicated for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and obstetrical procedures.
Uses
Indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.
Dosage
Available in concentrations of 0.25%, 0.5%, and 0.75%. Specific doses vary by block type. Aspirate before injection and use test dose recommendations. Maximum daily dosage depends on procedure type and patient factors.
Side Effects
CNS effects include restlessness, anxiety, tremors, and convulsions. Cardiovascular effects include cardiac arrhythmias, hypotension, and cardiac arrest. Allergic reactions and methemoglobinemia may also occur.
Interactions
Additive toxicity with other local anesthetics. Severe hypertension with MAOIs and tricyclic antidepressants. Interactions with ergot-type oxytocic drugs, nonselective beta-blockers, and potent inhalation anesthetics.
Warnings
Risk of cardiac arrest with use in obstetrical anesthesia, particularly with 0.75% concentration. Dose-related toxicity, methemoglobinemia risk, chondrolysis with intra-articular infusion. Contraindicated for obstetrical paracervical block, intravenous regional anesthesia (Bier Block), and hypersensitivity to amide-type local anesthetics.
Pregnancy
Contraindicated for obstetrical paracervical block anesthesia due to fetal bradycardia and death risk. Animal studies showed embryo-fetal lethality. Local anesthetics cross the placenta.
Frequently Asked Questions
What is Bupivacaine Hydrochloride used for?▼
Indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.
What are the side effects of Bupivacaine Hydrochloride?▼
CNS effects include restlessness, anxiety, tremors, and convulsions. Cardiovascular effects include cardiac arrhythmias, hypotension, and cardiac arrest. Allergic reactions and methemoglobinemia may also occur.
Can I take Bupivacaine Hydrochloride during pregnancy?▼
Contraindicated for obstetrical paracervical block anesthesia due to fetal bradycardia and death risk. Animal studies showed embryo-fetal lethality. Local anesthetics cross the placenta.
What are the important warnings for Bupivacaine Hydrochloride?▼
Risk of cardiac arrest with use in obstetrical anesthesia, particularly with 0.75% concentration. Dose-related toxicity, methemoglobinemia risk, chondrolysis with intra-articular infusion. Contraindicated for obstetrical paracervical block, intravenous regional anesthesia (Bier Block), and hypersensitivity to amide-type local anesthetics.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.