Bupivacaine Hydrochloride And Epinephrine Bitartrate
Generic Name: bupivacaine hydrochloride and epinephrine bitartrate
Brand Names:
Marcaine With Epinephrine
Bupivacaine hydrochloride and epinephrine bitartrate injection is an amide local anesthetic with vasoconstrictor for the production of local or regional anesthesia or analgesia for surgery, dental procedures, diagnostic and therapeutic procedures, and obstetrical procedures.
Overview
Bupivacaine hydrochloride and epinephrine bitartrate injection is an amide local anesthetic with vasoconstrictor for the production of local or regional anesthesia or analgesia for surgery, dental procedures, diagnostic and therapeutic procedures, and obstetrical procedures.
Uses
Indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.
Dosage
Dosages vary based on anesthetic procedure, area to be anesthetized, tissue vascularity, and patient condition. Maximum daily dosage is 400 mg in 24 hours. For dental use, average dose is 1.8 mL per injection site. Epidural administration uses incremental doses of 3-5 mL.
Side Effects
Most common reactions affect the central nervous system and cardiovascular system including restlessness, anxiety, tremors, convulsions, cardiac arrhythmias, hypotension, and cardiac arrest. Allergic reactions and methemoglobinemia may also occur.
Interactions
Additive toxicity with other local anesthetics. Severe hypertension with MAOIs and tricyclic antidepressants. Interactions with ergot-type oxytocic drugs, nonselective beta-blockers, and potent inhalation anesthetics.
Warnings
Risk of cardiac arrest with difficult resuscitation or death during epidural anesthesia in obstetrical patients, particularly with 0.75% concentration. Contraindicated for obstetrical paracervical block, intravenous regional anesthesia (Bier Block), and hypersensitivity to bupivacaine or amide-type local anesthetics.
Pregnancy
Not recommended for obstetrical paracervical block. Animal studies showed embryo-fetal lethality. Local anesthetics cross the placenta. Bupivacaine is excreted in breast milk.
Storage
Store at 20-25 degrees C (68-77 degrees F). Solutions with epinephrine cannot be autoclaved and must be protected from light.
Frequently Asked Questions
What is Bupivacaine Hydrochloride And Epinephrine Bitartrate used for?▼
Indicated in adults for the production of local or regional anesthesia or analgesia for surgery, dental and oral surgery procedures, diagnostic and therapeutic procedures, and for obstetrical procedures.
What are the side effects of Bupivacaine Hydrochloride And Epinephrine Bitartrate?▼
Most common reactions affect the central nervous system and cardiovascular system including restlessness, anxiety, tremors, convulsions, cardiac arrhythmias, hypotension, and cardiac arrest. Allergic reactions and methemoglobinemia may also occur.
Can I take Bupivacaine Hydrochloride And Epinephrine Bitartrate during pregnancy?▼
Not recommended for obstetrical paracervical block. Animal studies showed embryo-fetal lethality. Local anesthetics cross the placenta. Bupivacaine is excreted in breast milk.
What are the important warnings for Bupivacaine Hydrochloride And Epinephrine Bitartrate?▼
Risk of cardiac arrest with difficult resuscitation or death during epidural anesthesia in obstetrical patients, particularly with 0.75% concentration. Contraindicated for obstetrical paracervical block, intravenous regional anesthesia (Bier Block), and hypersensitivity to bupivacaine or amide-type local anesthetics.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.