Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate
Generic Name: buprenorphine hydrochloride and naloxone hydrochloride dihydrate
Brand Names:
Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate
Buprenorphine hydrochloride and naloxone hydrochloride dihydrate sublingual tablets are indicated for the maintenance treatment of opioid dependence as part of a comprehensive treatment plan including counseling and psychosocial support.
Overview
Buprenorphine hydrochloride and naloxone hydrochloride dihydrate sublingual tablets are indicated for the maintenance treatment of opioid dependence as part of a comprehensive treatment plan including counseling and psychosocial support.
Uses
Indicated for the maintenance treatment of opioid dependence as part of a comprehensive treatment plan including counseling and psychosocial support.
Dosage
Administered sublingually as a single daily dose. Maintenance dosing ranges from 4 mg/1 mg to 24 mg/6 mg daily. Tablets must be placed under the tongue until dissolved; swallowing reduces effectiveness.
Side Effects
Common adverse events include headache (30%), insomnia (25%), pain (24%), and withdrawal syndrome (22%). Post-marketing reports identified dental issues including caries and tooth loss.
Interactions
Major interactions include benzodiazepines and CNS depressants, CYP3A4 inhibitors/inducers, serotonergic drugs, and MAOIs. Requires careful monitoring with antiretrovirals.
Warnings
Life-threatening respiratory depression risk, especially with benzodiazepines. Risks include neonatal withdrawal, adrenal insufficiency, hepatic events, and dental adverse events. Contraindicated in hypersensitivity to buprenorphine or naloxone.
Frequently Asked Questions
What is Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate used for?▼
Indicated for the maintenance treatment of opioid dependence as part of a comprehensive treatment plan including counseling and psychosocial support.
What are the side effects of Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate?▼
Common adverse events include headache (30%), insomnia (25%), pain (24%), and withdrawal syndrome (22%). Post-marketing reports identified dental issues including caries and tooth loss.
What are the important warnings for Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate?▼
Life-threatening respiratory depression risk, especially with benzodiazepines. Risks include neonatal withdrawal, adrenal insufficiency, hepatic events, and dental adverse events. Contraindicated in hypersensitivity to buprenorphine or naloxone.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.