Calcitriol
Generic Name: calcitriol
Brand Names:
Calcitriol
Calcitriol is a synthetic vitamin D analog that regulates calcium absorption and utilization. It is indicated for managing secondary hyperparathyroidism and metabolic bone disease in predialysis patients, hypocalcemia in dialysis patients, and hypoparathyroidism.
Overview
Calcitriol is a synthetic vitamin D analog that regulates calcium absorption and utilization. It is indicated for managing secondary hyperparathyroidism and metabolic bone disease in predialysis patients, hypocalcemia in dialysis patients, and hypoparathyroidism.
Uses
Indicated for managing secondary hyperparathyroidism and metabolic bone disease in predialysis patients. Also used for hypocalcemia in dialysis patients and those with postsurgical hypoparathyroidism, idiopathic hypoparathyroidism, or pseudohypoparathyroidism.
Dosage
Starting dose is 0.25 mcg daily, adjustable based on response. Serum calcium requires monitoring twice weekly during titration, then monthly. Patients need minimum 600 mg daily dietary calcium.
Side Effects
Hypercalcemia-related effects include weakness, headache, somnolence, nausea, vomiting, and late manifestations including polyuria, weight loss, and cardiac arrhythmias. Hypercalcemia occurred in approximately 1 of 3 patients in clinical trials.
Interactions
Cholestyramine may impair calcitriol absorption. Phenytoin and phenobarbital reduce endogenous vitamin D levels. Thiazides and digitalis increase hypercalcemia risk. Ketoconazole may inhibit calcitriol metabolism.
Warnings
Overdosage of any form of vitamin D is dangerous. The Ca x P product should not exceed 70 mg2/dL2. Concurrent vitamin D use should be avoided. Magnesium antacids contraindicated in dialysis patients. Contraindicated in hypercalcemia, vitamin D toxicity, and hypersensitivity.
Pregnancy
Category C. Teratogenic effects observed in rabbits. No adequate studies in pregnant women. Use only if benefits justify fetal risks.
Storage
Protect from light. Store at 20-25 degrees C.
Frequently Asked Questions
What is Calcitriol used for?▼
Indicated for managing secondary hyperparathyroidism and metabolic bone disease in predialysis patients. Also used for hypocalcemia in dialysis patients and those with postsurgical hypoparathyroidism, idiopathic hypoparathyroidism, or pseudohypoparathyroidism.
What are the side effects of Calcitriol?▼
Hypercalcemia-related effects include weakness, headache, somnolence, nausea, vomiting, and late manifestations including polyuria, weight loss, and cardiac arrhythmias. Hypercalcemia occurred in approximately 1 of 3 patients in clinical trials.
Can I take Calcitriol during pregnancy?▼
Category C. Teratogenic effects observed in rabbits. No adequate studies in pregnant women. Use only if benefits justify fetal risks.
What are the important warnings for Calcitriol?▼
Overdosage of any form of vitamin D is dangerous. The Ca x P product should not exceed 70 mg2/dL2. Concurrent vitamin D use should be avoided. Magnesium antacids contraindicated in dialysis patients. Contraindicated in hypercalcemia, vitamin D toxicity, and hypersensitivity.
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Trubrexa TM Transdermal Patch is comprised of an adhesive material containing 4.75% lidocaine and 0.025% capsaicin. Each patch is 2 in x 2 in (5.08 cm x 5.08 cm) and consists of an adhesive side containing the active/inactive ingredients and an outer surface backing layer with breathable fabric. The adhesive side is covered with a removable, clear, unprinted, plastic film. The outer surface of the backing layer is imprinted with the Trubrexa TM Transdermal Patch logo.
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.