Calcium Chloride Dihydrate
Generic Name: calcium chloride dihydrate
Brand Names:
Calcium Chloride Dihydrate
11 DESCRIPTION 10% Calcium chloride injection, USP is a sterile, nonpyrogenic, hypertonic solution for single administration only. Each mL contains 100 mg (1.4 mEq/mL) of calcium chloride, dihydrate (1.4 mEq each of Ca ++ and Cl - ) in water for injection. It is provided in a 10 mL single-dose vial for intravenous injection. The solution contains no bacteriostat, antimicrobial agent or added buffer.
Overview
11 DESCRIPTION 10% Calcium chloride injection, USP is a sterile, nonpyrogenic, hypertonic solution for single administration only. Each mL contains 100 mg (1.4 mEq/mL) of calcium chloride, dihydrate (1.4 mEq each of Ca ++ and Cl - ) in water for injection. It is provided in a 10 mL single-dose vial for intravenous injection. The solution contains no bacteriostat, antimicrobial agent or added buffer.
Uses
1 INDICATIONS AND USAGE Calcium chloride injection is indicated for the treatment of adult and pediatric patients with acute symptomatic hypocalcemia. Limitations of Use The safety and effectiveness of calcium chloride injection for long-term use has not been established. Calcium chloride injection is a form of calcium indicated for the treatment of adult and pediatric and patients with acute symptomatic hypocalcemia. (1) Limitations of Use : The safety and effectiveness of calcium chloride injection for long-term use has not been established.
Dosage
2 DOSAGE AND ADMINISTRATION Administer calcium chloride injection by slow intravenous infusion (not to exceed 1 mL/minute), in a central or deep vein. (2.1) Do not use intramuscularly or subcutaneously. (2.1) Do not administer unless solution is clear and seal is intact. (2.1) Stop the administration if the patient complains of any administration- related discomfort, it may be resumed when symptoms disappear. (2.1) The recommended adult dose is from 200 mg to 1,000 mg. (2.2) The recommended pediatric dose is from 2.7 to 5 mg/kg of calcium chloride. (2.2) Repeated injections may be required because of rapid calcium excretion. (2.2) See the full prescribing information for the recommended starting dose in patients with renal impairment.
Side Effects
6 ADVERSE REACTIONS The following serious adverse reactions are also described elsewhere in the labeling: End-Organ damage due to intravascular ceftriaxone-calcium precipitates [see Warnings and Precautions (5.1)] Hypotension, bradycardia, arrhythmias, and syncope with rapid administration [see Warnings and Precautions (5.2)] Arrhythmias with concomitant digoxin use [see Warnings and Precautions (5.3)] Tissue necrosis and calcinosis [see Warnings and Precautions (5.4)] Aluminum toxicity [see Warnings and Precautions (5.5)] The following adverse reactions have been identified in literature and postmarketing reports of calcium chloride.
Interactions
7 DRUG INTERACTIONS Digoxin: Avoid concomitant use with calcium chloride injection. If concomitant use is unavoidable, monitor ECG closely during administration of calcium chloride injection. (5.3, 7.1) Calcium Channel Blockers: Avoid concomitant use with calcium chloride injection. If concomitant use is unavoidable, monitor blood pressure closely during administration of calcium chloride injection. (7.2) Drugs That Increase the Risk of Hypercalcemia: Increase the frequency of calcium concentration monitoring in patients taking calcium chloride injection concomitantly with other drugs that increase the risk of hypercalcemia. (7.3) 7.1 Digoxin Avoid the concomitant use of calcium chloride injection with digoxin.
Warnings
5 WARNINGS AND PRECAUTIONS End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium chloride injection is contraindicated in newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment. In patients older than 28 days of age, do not mix or administer simultaneously with ceftriaxone intravenous solutions, even via different infusion lines or at different infusion sites as it can lead to precipitation of ceftriaxone-calcium. (5.1) Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration: Too rapid an injection exceeding 1 mL/minute may lead to hypotension and syncope. (2.1, 5.2) Arrhythmias with Concomitant Digoxin Use: Avoid use of calcium chloride injection in patients receiving digoxin. 4 CONTRAINDICATIONS Calcium chloride injection is contraindicated in: Patients with ventricular fibrillation Patients with asystole and electromechanical dissociation Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at dif...
Pregnancy
8.1 Pregnancy Risk Summary Administration of calcium chloride injection for the treatment of acute symptomatic hypocalcemia during pregnancy is not expected to cause major birth defects, miscarriage, or adverse maternal or fetal outcomes. There are risks to the mother and the fetus associated with development of hypocalcemia during pregnancy (see Clinical Considerations). Animal reproduction studies have not been conducted with calcium chloride injection. The estimated background risk of major birth defects and miscarriage for the indicated populations are unknown.
Storage
16 HOW SUPPLIED/STORAGE AND HANDLING Calcium chloride injection, USP (clear solution) is supplied in single-dose vial as follows: Unit of Sale and Product Description Strength NDC 10 mL vials packaged in a carton of 10 10% (1,000 mg/10 mL) (100 mg/mL) 70069-773-10 The 100 mg/mL concentration represents 27 mg or 1.4 mEq of elemental calcium per mL of solution.
Frequently Asked Questions
What is Calcium Chloride Dihydrate used for?▼
1 INDICATIONS AND USAGE Calcium chloride injection is indicated for the treatment of adult and pediatric patients with acute symptomatic hypocalcemia. Limitations of Use The safety and effectiveness of calcium chloride injection for long-term use has not been established. Calcium chloride injection is a form of calcium indicated for the treatment of adult and pediatric and patients with acute symptomatic hypocalcemia. (1) Limitations of Use : The safety and effectiveness of calcium chloride injection for long-term use has not been established.
What are the side effects of Calcium Chloride Dihydrate?▼
6 ADVERSE REACTIONS The following serious adverse reactions are also described elsewhere in the labeling: End-Organ damage due to intravascular ceftriaxone-calcium precipitates [see Warnings and Precautions (5.1)] Hypotension, bradycardia, arrhythmias, and syncope with rapid administration [see Warnings and Precautions (5.2)] Arrhythmias with concomitant digoxin use [see Warnings and Precautions (5.3)] Tissue necrosis and calcinosis [see Warnings and Precautions (5.4)] Aluminum toxicity [see Warnings and Precautions (5.5)] The following adverse reactions have been identified in literature and postmarketing reports of calcium chloride.
Can I take Calcium Chloride Dihydrate during pregnancy?▼
8.1 Pregnancy Risk Summary Administration of calcium chloride injection for the treatment of acute symptomatic hypocalcemia during pregnancy is not expected to cause major birth defects, miscarriage, or adverse maternal or fetal outcomes. There are risks to the mother and the fetus associated with development of hypocalcemia during pregnancy (see Clinical Considerations). Animal reproduction studies have not been conducted with calcium chloride injection. The estimated background risk of major birth defects and miscarriage for the indicated populations are unknown.
What are the important warnings for Calcium Chloride Dihydrate?▼
5 WARNINGS AND PRECAUTIONS End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium chloride injection is contraindicated in newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment. In patients older than 28 days of age, do not mix or administer simultaneously with ceftriaxone intravenous solutions, even via different infusion lines or at different infusion sites as it can lead to precipitation of ceftriaxone-calcium. (5.1) Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration: Too rapid an injection exceeding 1 mL/minute may lead to hypotension and syncope. (2.1, 5.2) Arrhythmias with Concomitant Digoxin Use: Avoid use of calcium chloride injection in patients receiving digoxin. 4 CONTRAINDICATIONS Calcium chloride injection is contraindicated in: Patients with ventricular fibrillation Patients with asystole and electromechanical dissociation Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at dif...
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.