Carbamazepine
Generic Name: carbamazepine
Brand Names:
Carbamazepine
Carbamazepine is an anticonvulsant and analgesic for trigeminal neuralgia, available as extended-release tablets. Indicated for epilepsy (partial seizures with complex symptomatology, generalized tonic-clonic seizures, mixed seizure patterns) and trigeminal neuralgia pain relief.
Overview
Carbamazepine is an anticonvulsant and analgesic for trigeminal neuralgia, available as extended-release tablets. Indicated for epilepsy (partial seizures with complex symptomatology, generalized tonic-clonic seizures, mixed seizure patterns) and trigeminal neuralgia pain relief.
Uses
Indicated for epilepsy including partial seizures with complex symptomatology, generalized tonic-clonic seizures, and mixed seizure patterns. Also indicated for trigeminal neuralgia pain relief.
Dosage
Adults and children over 12 years: Initial 200 mg twice daily, increase by up to 200 mg per day weekly. Usual maintenance: 800-1200 mg daily. Maximum: 1200-1600 mg daily depending on age.
Side Effects
Most common: dizziness, drowsiness, unsteadiness, nausea, vomiting. Serious: aplastic anemia, agranulocytosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, hepatic effects, cardiovascular complications.
Interactions
CYP3A4 inhibitors increase carbamazepine levels. Carbamazepine induces metabolism of many drugs, reducing effectiveness of oral contraceptives, warfarin, and others.
Warnings
Serious and sometimes fatal dermatologic reactions (TEN/SJS) reported. Higher risk in Asian populations with HLA-B*1502 allele. Aplastic anemia and agranulocytosis risk 5-8x greater than general population. HLA-B*1502 screening recommended for at-risk populations. Contraindicated with history of bone marrow depression, hypersensitivity to carbamazepine or tricyclic compounds, MAO inhibitor use within 14 days, or concurrent nefazodone.
Pregnancy
Can cause fetal harm. Epidemiological data suggest association with congenital malformations including spina bifida. Patients encouraged to enroll in NAAED Pregnancy Registry.
Storage
Store at 20-25 degrees C (68-77 degrees F). Protect from moisture. Dispense in tight container.
Frequently Asked Questions
What is Carbamazepine used for?▼
Indicated for epilepsy including partial seizures with complex symptomatology, generalized tonic-clonic seizures, and mixed seizure patterns. Also indicated for trigeminal neuralgia pain relief.
What are the side effects of Carbamazepine?▼
Most common: dizziness, drowsiness, unsteadiness, nausea, vomiting. Serious: aplastic anemia, agranulocytosis, toxic epidermal necrolysis, Stevens-Johnson syndrome, hepatic effects, cardiovascular complications.
Can I take Carbamazepine during pregnancy?▼
Can cause fetal harm. Epidemiological data suggest association with congenital malformations including spina bifida. Patients encouraged to enroll in NAAED Pregnancy Registry.
What are the important warnings for Carbamazepine?▼
Serious and sometimes fatal dermatologic reactions (TEN/SJS) reported. Higher risk in Asian populations with HLA-B*1502 allele. Aplastic anemia and agranulocytosis risk 5-8x greater than general population. HLA-B*1502 screening recommended for at-risk populations. Contraindicated with history of bone marrow depression, hypersensitivity to carbamazepine or tricyclic compounds, MAO inhibitor use within 14 days, or concurrent nefazodone.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.