Carbidopa And Levodopa
Generic Name: carbidopa and levodopa
Brand Names:
Carbidopa And Levodopa
Carbidopa and levodopa orally disintegrating tablets are a combination for treating Parkinson's disease. They rapidly disintegrate on the tongue without requiring water. Indicated for treating Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism.
Overview
Carbidopa and levodopa orally disintegrating tablets are a combination for treating Parkinson's disease. They rapidly disintegrate on the tongue without requiring water. Indicated for treating Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism.
Uses
Indicated for treating Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism following carbon monoxide or manganese intoxication.
Dosage
Initial dosage: one tablet of 25 mg/100 mg three times daily. Increase by one tablet daily or every other day as needed, up to eight tablets daily. Transfer from levodopa requires discontinuing it 12 or more hours prior.
Side Effects
Most common: dyskinesias and nausea. Others include cardiac irregularities, orthostatic hypotension, gastrointestinal bleeding, hallucinations, psychotic episodes, and impulse control symptoms.
Interactions
Antihypertensive drugs may require dosage adjustment. Selegiline may cause severe orthostatic hypotension. Dopamine antagonists reduce therapeutic effects. Iron salts reduce bioavailability.
Warnings
Carbidopa permits more levodopa to reach the brain, causing CNS effects like dyskinesias at lower doses. Risk of sudden sleep onset during activities. Monitor for depression with suicidal tendencies and neuroleptic malignant syndrome. Contraindicated with nonselective MAO inhibitors (discontinue 2 or more weeks prior), hypersensitivity to any component, and narrow-angle glaucoma.
Pregnancy
No adequate well-controlled studies in pregnant women. Animal studies showed malformations in rabbits. Levodopa crosses placental barrier.
Storage
Store at 20-25 degrees C (68-77 degrees F). Protect from moisture and light. Dispense in tight, light-resistant container.
Frequently Asked Questions
What is Carbidopa And Levodopa used for?▼
Indicated for treating Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism following carbon monoxide or manganese intoxication.
What are the side effects of Carbidopa And Levodopa?▼
Most common: dyskinesias and nausea. Others include cardiac irregularities, orthostatic hypotension, gastrointestinal bleeding, hallucinations, psychotic episodes, and impulse control symptoms.
Can I take Carbidopa And Levodopa during pregnancy?▼
No adequate well-controlled studies in pregnant women. Animal studies showed malformations in rabbits. Levodopa crosses placental barrier.
What are the important warnings for Carbidopa And Levodopa?▼
Carbidopa permits more levodopa to reach the brain, causing CNS effects like dyskinesias at lower doses. Risk of sudden sleep onset during activities. Monitor for depression with suicidal tendencies and neuroleptic malignant syndrome. Contraindicated with nonselective MAO inhibitors (discontinue 2 or more weeks prior), hypersensitivity to any component, and narrow-angle glaucoma.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.