Carboprost Tromethamine
Generic Name: carboprost tromethamine
Brand Names:
Carboprost Tromethamine
Carboprost tromethamine is an oxytocic prostaglandin analogue for intramuscular injection. Indicated for aborting pregnancy between 13th and 20th weeks of gestation and for treating postpartum hemorrhage due to uterine atony unresponsive to conventional methods.
Overview
Carboprost tromethamine is an oxytocic prostaglandin analogue for intramuscular injection. Indicated for aborting pregnancy between 13th and 20th weeks of gestation and for treating postpartum hemorrhage due to uterine atony unresponsive to conventional methods.
Uses
Indicated for aborting pregnancy between 13th and 20th weeks of gestation and for treating postpartum hemorrhage due to uterine atony unresponsive to conventional methods.
Dosage
Initial dose: 250 micrograms (1 mL) intramuscularly. Subsequent doses at 1.5 to 3.5 hour intervals. Maximum dose: 12 milligrams. For postpartum hemorrhage: single or multiple doses at 15-90 minute intervals; maximum 2 milligrams (8 doses).
Side Effects
Most frequent: vomiting (approximately two-thirds), diarrhea, nausea (one-third), temperature increase greater than 2 degrees F (one-eighth), flushing. Post-marketing: hypersensitivity reactions including anaphylaxis and angioedema.
Interactions
May augment activity of other oxytocic agents. Concomitant use with other oxytocic agents not recommended.
Warnings
Use only with strict adherence to recommended dosages. Must be used by medically trained personnel in hospitals with intensive care and acute surgical facilities. Contraindicated in hypersensitivity, acute pelvic inflammatory disease, active cardiac, pulmonary, renal, or hepatic disease. Animal studies show embryotoxicity in rats and rabbits.
Pregnancy
Animal studies show embryotoxicity in rats and rabbits. Not teratogenic, but any dose increasing uterine tone could risk embryo or fetus.
Storage
Refrigerate at 2 to 8 degrees C (36 to 46 degrees F). Discard unused portion.
Frequently Asked Questions
What is Carboprost Tromethamine used for?▼
Indicated for aborting pregnancy between 13th and 20th weeks of gestation and for treating postpartum hemorrhage due to uterine atony unresponsive to conventional methods.
What are the side effects of Carboprost Tromethamine?▼
Most frequent: vomiting (approximately two-thirds), diarrhea, nausea (one-third), temperature increase greater than 2 degrees F (one-eighth), flushing. Post-marketing: hypersensitivity reactions including anaphylaxis and angioedema.
Can I take Carboprost Tromethamine during pregnancy?▼
Animal studies show embryotoxicity in rats and rabbits. Not teratogenic, but any dose increasing uterine tone could risk embryo or fetus.
What are the important warnings for Carboprost Tromethamine?▼
Use only with strict adherence to recommended dosages. Must be used by medically trained personnel in hospitals with intensive care and acute surgical facilities. Contraindicated in hypersensitivity, acute pelvic inflammatory disease, active cardiac, pulmonary, renal, or hepatic disease. Animal studies show embryotoxicity in rats and rabbits.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.