Celecoxib
Generic Name: celecoxib
Brand Names:
Celecoxib
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (age 2 and older), ankylosing spondylitis, acute pain, and primary dysmenorrhea.
Overview
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (age 2 and older), ankylosing spondylitis, acute pain, and primary dysmenorrhea.
Uses
Indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (age 2 and older), ankylosing spondylitis, acute pain, and primary dysmenorrhea.
Dosage
Osteoarthritis: 200 mg daily or 100 mg twice daily. Rheumatoid arthritis: 100-200 mg twice daily. Juvenile RA: 50 mg twice daily (10-25 kg) or 100 mg twice daily (over 25 kg). Ankylosing spondylitis: 200 mg daily, up to 400 mg if needed. Acute pain: 400 mg initially, then 200 mg as needed; 200 mg twice daily thereafter.
Side Effects
Most common (over 2%): abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, dizziness, pharyngitis, rhinitis, sinusitis, upper respiratory infection, rash. Serious: cardiovascular thrombotic events, GI bleeding/ulceration/perforation, hepatotoxicity, anaphylaxis, serious skin reactions.
Interactions
Warfarin/anticoagulants increase bleeding risk. ACE inhibitors/ARBs/beta-blockers may have diminished effects. Diuretics' natriuretic effect reduced. Digoxin levels increased. Lithium clearance decreased. Methotrexate toxicity risk increased. CYP2C9 inhibitors/inducers affect celecoxib metabolism.
Warnings
NSAIDs cause increased risk of serious cardiovascular thrombotic events (MI, stroke) which can be fatal. Risk may occur early and increase with duration. Contraindicated post-CABG surgery. Increased risk of serious GI events (bleeding, ulceration, perforation). Contraindicated in hypersensitivity to celecoxib, history of asthma/urticaria/allergic reactions to aspirin/NSAIDs, and allergic-type reactions to sulfonamides.
Pregnancy
Avoid NSAIDs at approximately 30 weeks gestation or later due to premature ductus arteriosus closure risk. Limit use 20-30 weeks to lowest effective dose and shortest duration.
Frequently Asked Questions
What is Celecoxib used for?▼
Indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (age 2 and older), ankylosing spondylitis, acute pain, and primary dysmenorrhea.
What are the side effects of Celecoxib?▼
Most common (over 2%): abdominal pain, diarrhea, dyspepsia, flatulence, peripheral edema, dizziness, pharyngitis, rhinitis, sinusitis, upper respiratory infection, rash. Serious: cardiovascular thrombotic events, GI bleeding/ulceration/perforation, hepatotoxicity, anaphylaxis, serious skin reactions.
Can I take Celecoxib during pregnancy?▼
Avoid NSAIDs at approximately 30 weeks gestation or later due to premature ductus arteriosus closure risk. Limit use 20-30 weeks to lowest effective dose and shortest duration.
What are the important warnings for Celecoxib?▼
NSAIDs cause increased risk of serious cardiovascular thrombotic events (MI, stroke) which can be fatal. Risk may occur early and increase with duration. Contraindicated post-CABG surgery. Increased risk of serious GI events (bleeding, ulceration, perforation). Contraindicated in hypersensitivity to celecoxib, history of asthma/urticaria/allergic reactions to aspirin/NSAIDs, and allergic-type reactions to sulfonamides.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.