Ciprofloxacin Hydrochloride
Generic Name: ciprofloxacin hydrochloride
Brand Names:
Cipro
Ciprofloxacin hydrochloride is a fluoroquinolone antibacterial indicated in adults and select pediatric patients for treating infections caused by susceptible bacteria including skin, bone, intra-abdominal, respiratory, and urinary tract infections.
Overview
Ciprofloxacin hydrochloride is a fluoroquinolone antibacterial indicated in adults and select pediatric patients for treating infections caused by susceptible bacteria including skin, bone, intra-abdominal, respiratory, and urinary tract infections.
Uses
Indicated in adults for skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections, infectious diarrhea, typhoid fever, gonorrhea, inhalational anthrax post-exposure, plague, chronic bacterial prostatitis, lower respiratory tract infections, urinary tract infections, and acute sinusitis.
Dosage
Adult dosing varies by infection type, ranging from 250 mg to 750 mg orally every 8-12 hours for 3-60 days depending on indication. Pediatric dosing is weight-based. Renal impairment requires dosage adjustments.
Side Effects
Most common adverse reactions (1% or more) include nausea, diarrhea, liver function test abnormalities, vomiting, and rash. Serious reactions include tendinitis, tendon rupture, peripheral neuropathy, and psychiatric effects.
Interactions
Ciprofloxacin is a CYP1A2 inhibitor. Contraindicated with tizanidine. Avoid theophylline, QT-prolonging drugs, and duloxetine. Use caution with antidiabetic agents, warfarin, and methotrexate.
Warnings
Fluoroquinolones are associated with disabling and potentially irreversible serious adverse reactions including tendinitis, tendon rupture, peripheral neuropathy, CNS effects, and exacerbation of myasthenia gravis. Additional warnings for hepatotoxicity, QT prolongation, and aortic aneurysm risk. Contraindicated with tizanidine and in hypersensitivity to quinolones.
Frequently Asked Questions
What is Ciprofloxacin Hydrochloride used for?▼
Indicated in adults for skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections, infectious diarrhea, typhoid fever, gonorrhea, inhalational anthrax post-exposure, plague, chronic bacterial prostatitis, lower respiratory tract infections, urinary tract infections, and acute sinusitis.
What are the side effects of Ciprofloxacin Hydrochloride?▼
Most common adverse reactions (1% or more) include nausea, diarrhea, liver function test abnormalities, vomiting, and rash. Serious reactions include tendinitis, tendon rupture, peripheral neuropathy, and psychiatric effects.
What are the important warnings for Ciprofloxacin Hydrochloride?▼
Fluoroquinolones are associated with disabling and potentially irreversible serious adverse reactions including tendinitis, tendon rupture, peripheral neuropathy, CNS effects, and exacerbation of myasthenia gravis. Additional warnings for hepatotoxicity, QT prolongation, and aortic aneurysm risk. Contraindicated with tizanidine and in hypersensitivity to quinolones.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.