Citalopram
Generic Name: citalopram
Brand Names:
Citalopram Hydrobromide
Citalopram HBr is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to other SSRIs or tricyclic antidepressants. Available in tablet dosage form with strengths of 10 mg, 20 mg, and 40 mg.
Overview
Citalopram HBr is an orally administered selective serotonin reuptake inhibitor (SSRI) with a chemical structure unrelated to other SSRIs or tricyclic antidepressants. Available in tablet dosage form with strengths of 10 mg, 20 mg, and 40 mg.
Uses
Indicated for treatment of major depressive disorder (MDD). Efficacy was established in 4-6 week controlled trials. A major depressive episode implies prominent and persistent depressed mood for at least 2 weeks, including at least five of nine specified symptoms such as depressed mood, loss of interest, weight/appetite changes, sleep disturbances, fatigue, guilt, concentration difficulties, or suicidal ideation.
Dosage
Maximum dose recommendations vary by patient population: 40 mg/day for general population, 20 mg/day for patients over 60 years, those with hepatic impairment, or taking CYP2C19 inhibitors.
Side Effects
Most common adverse events include dry mouth (20%), nausea (21%), somnolence (18%), insomnia (15%), and increased sweating (11%). Sexual dysfunction reported: abnormal ejaculation 6.1% in males, decreased libido 3.8% in males. Serious events include QT prolongation and cardiac arrhythmias.
Interactions
Significant interactions with serotonergic drugs (triptans, tramadol, lithium), MAOIs, CYP2C19 inhibitors (cimetidine), warfarin, NSAIDs, and drugs prolonging QTc interval. Coadministration with metoprolol resulted in two-fold increase in metoprolol plasma levels.
Warnings
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies of major depressive disorder and other psychiatric disorders. Clinical worsening and suicide risk, particularly in younger patients; QT-prolongation and Torsade de Pointes risk with dose-dependent increases; serotonin syndrome with concomitant serotonergic agents; screening for bipolar disorder prior to treatment; angle closure glaucoma risk. The use of MAOIs intended to treat psychiatric disorders with citalopram or within 14 days of stopping treatment with citalopram is contraindicated. Also contraindicated with pimozide and in patients with hypersensitivity to citalopram.
Pregnancy
Pregnancy Category C. Citalopram should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies showed adverse effects at doses greater than human therapeutic doses.
Storage
Tablets available in 10 mg (beige, round), 20 mg (pink, round, scored), and 40 mg (white, round, scored) film-coated formulations.
Frequently Asked Questions
What is Citalopram used for?▼
Indicated for treatment of major depressive disorder (MDD). Efficacy was established in 4-6 week controlled trials. A major depressive episode implies prominent and persistent depressed mood for at least 2 weeks, including at least five of nine specified symptoms such as depressed mood, loss of interest, weight/appetite changes, sleep disturbances, fatigue, guilt, concentration difficulties, or suicidal ideation.
What are the side effects of Citalopram?▼
Most common adverse events include dry mouth (20%), nausea (21%), somnolence (18%), insomnia (15%), and increased sweating (11%). Sexual dysfunction reported: abnormal ejaculation 6.1% in males, decreased libido 3.8% in males. Serious events include QT prolongation and cardiac arrhythmias.
Can I take Citalopram during pregnancy?▼
Pregnancy Category C. Citalopram should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies showed adverse effects at doses greater than human therapeutic doses.
What are the important warnings for Citalopram?▼
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies of major depressive disorder and other psychiatric disorders. Clinical worsening and suicide risk, particularly in younger patients; QT-prolongation and Torsade de Pointes risk with dose-dependent increases; serotonin syndrome with concomitant serotonergic agents; screening for bipolar disorder prior to treatment; angle closure glaucoma risk. The use of MAOIs intended to treat psychiatric disorders with citalopram or within 14 days of stopping treatment with citalopram is contraindicated. Also contraindicated with pimozide and in patients with hypersensitivity to citalopram.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.