Clindamycin Phosphate
Generic Name: clindamycin phosphate
Brand Names:
Xaciato
XACIATO is a clear, colorless, viscous vaginal gel containing clindamycin phosphate at 2% concentration, supplied in an 8g tube with a single-dose applicator delivering 5g containing 100mg of clindamycin.
Overview
XACIATO is a clear, colorless, viscous vaginal gel containing clindamycin phosphate at 2% concentration, supplied in an 8g tube with a single-dose applicator delivering 5g containing 100mg of clindamycin.
Uses
XACIATO is indicated for treatment of bacterial vaginosis in females 12 years of age and older.
Dosage
One applicatorful (5g of vaginal gel containing 100mg of clindamycin) administered once intravaginally as a single dose at any time of day. Not for ophthalmic, dermal, or oral use.
Side Effects
Most common adverse reactions occurring in more than 2% of patients: vulvovaginal candidiasis (17% vs 4% placebo) and vulvovaginal discomfort (6% vs 5% placebo). Serious adverse reactions include Clostridioides difficile-associated diarrhea.
Interactions
Systemic clindamycin has neuromuscular blocking properties; use with caution in patients receiving neuromuscular blocking agents.
Warnings
Clostridioides difficile-associated diarrhea may occur ranging from mild to fatal colitis. Not compatible with polyurethane condoms; latex or polyisoprene condoms recommended. May result in vaginal Candida overgrowth. Contraindicated in individuals with history of hypersensitivity to clindamycin or lincomycin.
Pregnancy
XACIATO has not been studied in pregnant women; low systemic absorption makes significant fetal exposure unlikely. Animal studies showed no developmental toxicity.
Storage
Store at 68 to 77 degrees F (20 to 25 degrees C); excursions permitted to 59 to 86 degrees F (15 to 30 degrees C).
Frequently Asked Questions
What is Clindamycin Phosphate used for?▼
XACIATO is indicated for treatment of bacterial vaginosis in females 12 years of age and older.
What are the side effects of Clindamycin Phosphate?▼
Most common adverse reactions occurring in more than 2% of patients: vulvovaginal candidiasis (17% vs 4% placebo) and vulvovaginal discomfort (6% vs 5% placebo). Serious adverse reactions include Clostridioides difficile-associated diarrhea.
Can I take Clindamycin Phosphate during pregnancy?▼
XACIATO has not been studied in pregnant women; low systemic absorption makes significant fetal exposure unlikely. Animal studies showed no developmental toxicity.
What are the important warnings for Clindamycin Phosphate?▼
Clostridioides difficile-associated diarrhea may occur ranging from mild to fatal colitis. Not compatible with polyurethane condoms; latex or polyisoprene condoms recommended. May result in vaginal Candida overgrowth. Contraindicated in individuals with history of hypersensitivity to clindamycin or lincomycin.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.