Colchicine
Generic Name: colchicine
Brand Names:
Colchicine
Colchicine is an alkaloid obtained from the plant colchicum autumnale. Each capsule contains 0.6 mg colchicine, USP with inactive ingredients including lactose monohydrate, pregelatinized starch, and sodium starch glycolate.
Overview
Colchicine is an alkaloid obtained from the plant colchicum autumnale. Each capsule contains 0.6 mg colchicine, USP with inactive ingredients including lactose monohydrate, pregelatinized starch, and sodium starch glycolate.
Uses
Colchicine capsules are indicated for prophylaxis of gout flares in adults. The medication is not an analgesic and should not be used to treat pain from other causes.
Dosage
The recommended dosage is 0.6 mg (one capsule) once or twice daily. Maximum dose 1.2 mg/day. Administered orally, without regard to meals.
Side Effects
Gastrointestinal disorders are the most common adverse reactions, including diarrhea, nausea, vomiting, and abdominal pain. Neuromuscular toxicity, blood dyscrasias, and myopathy may occur.
Interactions
Fatal interactions reported with clarithromycin (dual CYP3A4 and P-gp inhibitor). Concomitant use with CYP3A4 or P-gp inhibitors should be avoided or dose-adjusted with close monitoring.
Warnings
Fatal overdoses have been reported. Myelosuppression and blood dyscrasias can occur. Co-administration with dual P-gp and CYP3A4 inhibitors has resulted in life-threatening interactions. Neuromuscular toxicity and rhabdomyolysis may occur. Patients with renal or hepatic impairment should not take this medication with drugs inhibiting both P-glycoprotein and CYP3A4.
Pregnancy
Available data from published literature spanning several decades have not identified drug-associated risks for major birth defects or miscarriage. However, colchicine crosses the placenta.
Storage
Store at 20 to 25 degrees C (68 to 77 degrees F). Protect from light and moisture.
Frequently Asked Questions
What is Colchicine used for?▼
Colchicine capsules are indicated for prophylaxis of gout flares in adults. The medication is not an analgesic and should not be used to treat pain from other causes.
What are the side effects of Colchicine?▼
Gastrointestinal disorders are the most common adverse reactions, including diarrhea, nausea, vomiting, and abdominal pain. Neuromuscular toxicity, blood dyscrasias, and myopathy may occur.
Can I take Colchicine during pregnancy?▼
Available data from published literature spanning several decades have not identified drug-associated risks for major birth defects or miscarriage. However, colchicine crosses the placenta.
What are the important warnings for Colchicine?▼
Fatal overdoses have been reported. Myelosuppression and blood dyscrasias can occur. Co-administration with dual P-gp and CYP3A4 inhibitors has resulted in life-threatening interactions. Neuromuscular toxicity and rhabdomyolysis may occur. Patients with renal or hepatic impairment should not take this medication with drugs inhibiting both P-glycoprotein and CYP3A4.
Related Medications
Azacitidine
azacitidine
Nucleoside Metabolic Inhibitor [EPC]
11 DESCRIPTION Azacitidine for injection contains azacitidine, which is a nucleoside metabolic inhibitor. Azacitidine is 4-amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one. The structural formula is as follows: The empirical formula is C 8 H 12 N 4 O 5 . The molecular weight is 244. Azacitidine is a white to off-white solid.
Arsenic Trioxide 30c, Matricaria Chamomilla12x, Arabica Coffee Bean 30x, Potassium Carbonate30c, Strychnos Ignatii Seed30x, Lachesis Muta Venom12x, Phosphoric Acid 3x, Anemone Pulsatilla 12c, Valerian 30c, Aconitum Napellus 6x, Chloride Ion 12x, Strychnos Nux-vomica Seed 30c
arsenic trioxide 30c, matricaria chamomilla12x, arabica coffee bean 30x, potassium carbonate30c, strychnos ignatii seed30x, lachesis muta venom12x, phosphoric acid 3x, anemone pulsatilla 12c, valerian 30c, aconitum napellus 6x, chloride ion 12x, strychnos nux-vomica seed 30c
Non-Standardized Food Allergenic Extract [EPC]
Indications For temporary relief of occasional anxiety, tension and irritability. These uses are based upon traditional homeopathic practice. They have not been reviewed by the Food and Drug Administration. Aconitum nap 6X, Arsenicum alb 30C, Calcarea carb 30X, Chamomilla 12X, Ignatia 30X, Kali carb 30C, Lachesis 12X, Natrum mur 12X, Nux vom 30C, Phosphoricum ac 3X, Pulsatilla 12C, Sepia 30C. Equal volumes of each ingredient.
Nourishing Secrets Indulging Ritual Vanilla Antiperspirant
nourishing secrets indulging ritual vanilla antiperspirant
Purpose antiperspirant
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.