Colchicine
Generic Name: colchicine
Brand Names:
Colchicine
Colchicine is an alkaloid obtained from the plant colchicum autumnale. Each capsule contains 0.6 mg colchicine, USP with inactive ingredients including lactose monohydrate, pregelatinized starch, and sodium starch glycolate.
Overview
Colchicine is an alkaloid obtained from the plant colchicum autumnale. Each capsule contains 0.6 mg colchicine, USP with inactive ingredients including lactose monohydrate, pregelatinized starch, and sodium starch glycolate.
Uses
Colchicine capsules are indicated for prophylaxis of gout flares in adults. The medication is not an analgesic and should not be used to treat pain from other causes.
Dosage
The recommended dosage is 0.6 mg (one capsule) once or twice daily. Maximum dose 1.2 mg/day. Administered orally, without regard to meals.
Side Effects
Gastrointestinal disorders are the most common adverse reactions, including diarrhea, nausea, vomiting, and abdominal pain. Neuromuscular toxicity, blood dyscrasias, and myopathy may occur.
Interactions
Fatal interactions reported with clarithromycin (dual CYP3A4 and P-gp inhibitor). Concomitant use with CYP3A4 or P-gp inhibitors should be avoided or dose-adjusted with close monitoring.
Warnings
Fatal overdoses have been reported. Myelosuppression and blood dyscrasias can occur. Co-administration with dual P-gp and CYP3A4 inhibitors has resulted in life-threatening interactions. Neuromuscular toxicity and rhabdomyolysis may occur. Patients with renal or hepatic impairment should not take this medication with drugs inhibiting both P-glycoprotein and CYP3A4.
Pregnancy
Available data from published literature spanning several decades have not identified drug-associated risks for major birth defects or miscarriage. However, colchicine crosses the placenta.
Storage
Store at 20 to 25 degrees C (68 to 77 degrees F). Protect from light and moisture.
Frequently Asked Questions
What is Colchicine used for?▼
Colchicine capsules are indicated for prophylaxis of gout flares in adults. The medication is not an analgesic and should not be used to treat pain from other causes.
What are the side effects of Colchicine?▼
Gastrointestinal disorders are the most common adverse reactions, including diarrhea, nausea, vomiting, and abdominal pain. Neuromuscular toxicity, blood dyscrasias, and myopathy may occur.
Can I take Colchicine during pregnancy?▼
Available data from published literature spanning several decades have not identified drug-associated risks for major birth defects or miscarriage. However, colchicine crosses the placenta.
What are the important warnings for Colchicine?▼
Fatal overdoses have been reported. Myelosuppression and blood dyscrasias can occur. Co-administration with dual P-gp and CYP3A4 inhibitors has resulted in life-threatening interactions. Neuromuscular toxicity and rhabdomyolysis may occur. Patients with renal or hepatic impairment should not take this medication with drugs inhibiting both P-glycoprotein and CYP3A4.
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HPUS* active ingredients Purpose† Equal volumes of each ingredient in 10X, 30X, and LM1 potencies. Antimonium crudum............................................vesicles, warts Causticum........................................................warts on fingers Dulcamara...........................................................warts on face Kali muriaticum..................................................vesicles on skin Nitricum acidum.....................................................jagged war
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INDICATIONS: May temporarily relieve minor back pain, stiffness, numbness or tingling.** **Claims based on traditional homeopathic practice, not accepted medical evidence. Not FDA evaluated.
Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.