Daptomycin
Generic Name: daptomycin
Brand Names:
Daptomycin
Daptomycin for Injection contains daptomycin, a cyclic lipopeptide antibacterial agent derived from fermentation of Streptomyces roseosporus.
Overview
Daptomycin for Injection contains daptomycin, a cyclic lipopeptide antibacterial agent derived from fermentation of Streptomyces roseosporus.
Uses
Treatment of complicated skin and skin structure infections in adults and pediatric patients (1-17 years); Staphylococcus aureus bloodstream infections including right-sided endocarditis in adults and pediatrics (1-17 years). Not indicated for pneumonia or left-sided endocarditis.
Dosage
Adults receive 4 mg/kg every 24 hours for cSSSI or 6 mg/kg every 24 hours for bacteremia via IV infusion over 30 minutes. Pediatric dosing varies by age (5-12 mg/kg depending on condition and age group).
Side Effects
Most common reactions include diarrhea, headache, dizziness, rash, elevated CPK, and hypotension in adults; diarrhea, vomiting, and abdominal pain in pediatric patients.
Interactions
HMG-CoA reductase inhibitors may increase myopathy risk; consider temporary suspension during treatment.
Warnings
Monitor for myopathy/rhabdomyolysis, eosinophilic pneumonia, DRESS syndrome, peripheral neuropathy, and C. difficile-associated diarrhea. Avoid use in infants under 12 months. Contraindicated in patients with known hypersensitivity to daptomycin.
Frequently Asked Questions
What is Daptomycin used for?▼
Treatment of complicated skin and skin structure infections in adults and pediatric patients (1-17 years); Staphylococcus aureus bloodstream infections including right-sided endocarditis in adults and pediatrics (1-17 years). Not indicated for pneumonia or left-sided endocarditis.
What are the side effects of Daptomycin?▼
Most common reactions include diarrhea, headache, dizziness, rash, elevated CPK, and hypotension in adults; diarrhea, vomiting, and abdominal pain in pediatric patients.
What are the important warnings for Daptomycin?▼
Monitor for myopathy/rhabdomyolysis, eosinophilic pneumonia, DRESS syndrome, peripheral neuropathy, and C. difficile-associated diarrhea. Avoid use in infants under 12 months. Contraindicated in patients with known hypersensitivity to daptomycin.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.