Desmopressin Acetate
Generic Name: desmopressin acetate
Brand Names:
Desmopressin Acetate
Desmopressin acetate is a synthetic vasopressin analog for intravenous or subcutaneous use. Available as clear, colorless sterile solution at 4 mcg/mL concentration.
Overview
Desmopressin acetate is a synthetic vasopressin analog for intravenous or subcutaneous use. Available as clear, colorless sterile solution at 4 mcg/mL concentration.
Uses
Treatment for central diabetes insipidus, hemophilia A (factor VIII greater than 5%), and mild-to-moderate von Willebrand's disease Type I. Not indicated for nephrogenic diabetes insipidus or severe von Willebrand's disease.
Dosage
Diabetes insipidus: 2-4 mcg daily as one to two divided doses (subcutaneous/IV). Hemophilia A and vWD: 0.3 mcg/kg (maximum 20 mcg) by intravenous infusion over 15-30 minutes.
Side Effects
Common effects include abdominal cramps, burning pain, erythema, facial flushing, fluid retention, headache and serious risks of hyponatremia, hyponatremic seizures, thrombotic events.
Interactions
Tricyclic antidepressants, SSRIs, NSAIDs, and other hyponatremia-causing drugs require more frequent serum sodium monitoring. Vasoconstrictors may necessitate dose reduction.
Warnings
Desmopressin Acetate Injection can cause hyponatremia which may be life-threatening. Monitor serum sodium within 7 days and monthly thereafter. Contraindicated in hypersensitivity, renal impairment (CrCl less than 50 mL/min), hyponatremia history, SIADH, polydipsia, loop diuretics, glucocorticoids, heart failure, uncontrolled hypertension.
Pregnancy
Animal studies showed no adverse effects at high doses. Poor placental transfer documented. Use supported by decades of clinical experience without identified risks.
Storage
Refrigerate 2 to 8 degrees C (36 to 46 degrees F). Keep away from children.
Frequently Asked Questions
What is Desmopressin Acetate used for?▼
Treatment for central diabetes insipidus, hemophilia A (factor VIII greater than 5%), and mild-to-moderate von Willebrand's disease Type I. Not indicated for nephrogenic diabetes insipidus or severe von Willebrand's disease.
What are the side effects of Desmopressin Acetate?▼
Common effects include abdominal cramps, burning pain, erythema, facial flushing, fluid retention, headache and serious risks of hyponatremia, hyponatremic seizures, thrombotic events.
Can I take Desmopressin Acetate during pregnancy?▼
Animal studies showed no adverse effects at high doses. Poor placental transfer documented. Use supported by decades of clinical experience without identified risks.
What are the important warnings for Desmopressin Acetate?▼
Desmopressin Acetate Injection can cause hyponatremia which may be life-threatening. Monitor serum sodium within 7 days and monthly thereafter. Contraindicated in hypersensitivity, renal impairment (CrCl less than 50 mL/min), hyponatremia history, SIADH, polydipsia, loop diuretics, glucocorticoids, heart failure, uncontrolled hypertension.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.