Dexamethasone
Generic Name: dexamethasone
Brand Names:
Ozurdex
OZURDEX is a sterile intravitreal implant containing 0.7 mg dexamethasone in the NOVADUR solid polymer sustained-release drug delivery system, preloaded into a single-use applicator for vitreous injection.
Overview
OZURDEX is a sterile intravitreal implant containing 0.7 mg dexamethasone in the NOVADUR solid polymer sustained-release drug delivery system, preloaded into a single-use applicator for vitreous injection.
Uses
OZURDEX treats: macular edema following branch or central retinal vein occlusion; non-infectious posterior segment uveitis; and diabetic macular edema.
Dosage
For ophthalmic intravitreal injection under controlled aseptic conditions. Post-injection monitoring includes checking optic nerve perfusion, tonometry within 30 minutes, and biomicroscopy days 2-7.
Side Effects
Common reactions (20-70% of patients): cataracts, increased intraocular pressure, conjunctival hemorrhage. In diabetic macular edema trials, 68% of phakic patients developed cataracts; 61% required surgery.
Warnings
Intravitreal injections carry risks of endophthalmitis, eye inflammation, increased intraocular pressure, and retinal detachments. Corticosteroid use may produce posterior subcapsular cataracts and secondary ocular infections. Contraindicated in active or suspected ocular infections, glaucoma with cup-to-disc ratios exceeding 0.8, torn posterior lens capsule, and known hypersensitivity.
Pregnancy
No adequate controlled studies in pregnant women. Animal studies showed cleft palate and embryofetal death in mice; intestinal and kidney malformations in rabbits.
Storage
Store at 15 to 30 degrees C (59 to 86 degrees F).
Frequently Asked Questions
What is Dexamethasone used for?▼
OZURDEX treats: macular edema following branch or central retinal vein occlusion; non-infectious posterior segment uveitis; and diabetic macular edema.
What are the side effects of Dexamethasone?▼
Common reactions (20-70% of patients): cataracts, increased intraocular pressure, conjunctival hemorrhage. In diabetic macular edema trials, 68% of phakic patients developed cataracts; 61% required surgery.
Can I take Dexamethasone during pregnancy?▼
No adequate controlled studies in pregnant women. Animal studies showed cleft palate and embryofetal death in mice; intestinal and kidney malformations in rabbits.
What are the important warnings for Dexamethasone?▼
Intravitreal injections carry risks of endophthalmitis, eye inflammation, increased intraocular pressure, and retinal detachments. Corticosteroid use may produce posterior subcapsular cataracts and secondary ocular infections. Contraindicated in active or suspected ocular infections, glaucoma with cup-to-disc ratios exceeding 0.8, torn posterior lens capsule, and known hypersensitivity.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.