Dexmedetomidine Hydrochloride
Generic Name: dexmedetomidine hydrochloride
Brand Names:
Dexmedetomidine Hydrochloride
Dexmedetomidine Hydrochloride in 0.9% Sodium Chloride Injection is a sterile, nonpyrogenic ready to use solution containing dexmedetomidine hydrochloride, a central alpha-2 adrenergic agonist, at a concentration of 4 mcg/mL.
Overview
Dexmedetomidine Hydrochloride in 0.9% Sodium Chloride Injection is a sterile, nonpyrogenic ready to use solution containing dexmedetomidine hydrochloride, a central alpha-2 adrenergic agonist, at a concentration of 4 mcg/mL.
Uses
Indicated for sedation of intubated, mechanically ventilated adult ICU patients (continuous infusion not exceeding 24 hours) and sedation of non-intubated adults undergoing surgical or other procedural interventions.
Dosage
ICU Sedation: Loading dose of 1 mcg/kg over 10 minutes, followed by maintenance infusion of 0.2-0.7 mcg/kg/hour. Procedural Sedation: Loading dose of 1 mcg/kg over 10 minutes, followed by maintenance infusion starting at 0.6 mcg/kg/hour, titrated to desired effect. Dose reduction should be considered for patients over 65 and those with hepatic impairment.
Side Effects
Most common adverse reactions (greater than 2% incidence): hypotension, bradycardia, and dry mouth. Additional notable reactions include hypertension, nausea, atrial fibrillation, and pyrexia.
Interactions
Co-administration with anesthetics, sedatives, hypnotics, or opioids may enhance effects, requiring dose reduction.
Warnings
Risks of bradycardia, sinus arrest, and hypotension potentially serious in patients with advanced heart block or severe ventricular dysfunction. Transient hypertension may occur during loading. Tolerance and tachyphylaxis associated with infusions exceeding 24 hours. Withdrawal symptoms possible upon discontinuation.
Pregnancy
Human data from clinical use shows no identified drug-associated risks of birth defects or miscarriage, though exposures typically occurred post-first trimester.
Frequently Asked Questions
What is Dexmedetomidine Hydrochloride used for?▼
Indicated for sedation of intubated, mechanically ventilated adult ICU patients (continuous infusion not exceeding 24 hours) and sedation of non-intubated adults undergoing surgical or other procedural interventions.
What are the side effects of Dexmedetomidine Hydrochloride?▼
Most common adverse reactions (greater than 2% incidence): hypotension, bradycardia, and dry mouth. Additional notable reactions include hypertension, nausea, atrial fibrillation, and pyrexia.
Can I take Dexmedetomidine Hydrochloride during pregnancy?▼
Human data from clinical use shows no identified drug-associated risks of birth defects or miscarriage, though exposures typically occurred post-first trimester.
What are the important warnings for Dexmedetomidine Hydrochloride?▼
Risks of bradycardia, sinus arrest, and hypotension potentially serious in patients with advanced heart block or severe ventricular dysfunction. Transient hypertension may occur during loading. Tolerance and tachyphylaxis associated with infusions exceeding 24 hours. Withdrawal symptoms possible upon discontinuation.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.