Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate
Generic Name: dextroamphetamine saccharate, amphetamine aspartate monohydrate, dextroamphetamine sulfate, and amphetamine sulfate
Brand Names:
Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate
Mixed salts of a single-entity amphetamine, a CNS stimulant in extended-release capsule form. It comprises four equal-weight salts creating a 3.1:1 dextro-to-levo amphetamine ratio, available in strengths from 5mg to 30mg.
Overview
Mixed salts of a single-entity amphetamine, a CNS stimulant in extended-release capsule form. It comprises four equal-weight salts creating a 3.1:1 dextro-to-levo amphetamine ratio, available in strengths from 5mg to 30mg.
Uses
Indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in adults and pediatric patients 6 years and older.
Dosage
Pediatric (6-17 years): Begin at 10mg daily; max 30mg for ages 6-12. Adults: Start 20mg daily. Renal impairment adjustments: Reduce dosing with severe renal impairment; not recommended for end-stage renal disease. Administer upon awakening; avoid afternoon doses.
Side Effects
Most common in children: appetite loss, insomnia, abdominal pain, emotional instability, vomiting. In adolescents: appetite loss (36%), insomnia (12%), weight loss (9%). Adults: dry mouth (35%), appetite loss (33%), insomnia (27%), headache (26%).
Interactions
MAOIs and CNS stimulants can cause hypertensive crisis. CYP2D6 inhibitors increase exposure risk. Serotonergic drugs increase serotonin syndrome risk. Acidifying agents reduce efficacy; alkalinizing agents increase blood levels.
Warnings
High potential for abuse and misuse, which can lead to substance use disorder, including addiction. Sudden cardiac death risk in patients with serious cardiac disease; increased blood pressure/heart rate; psychiatric adverse reactions; growth suppression; seizure threshold lowering; peripheral vasculopathy; serotonin syndrome risk. Contraindicated with known hypersensitivity to amphetamine and MAOI use.
Pregnancy
Available data have not identified a drug-associated risk of major birth defects and miscarriage. However, animal studies show decreased pup survival and developmental delays at clinically relevant doses.
Frequently Asked Questions
What is Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate used for?▼
Indicated for the treatment of attention deficit hyperactivity disorder (ADHD) in adults and pediatric patients 6 years and older.
What are the side effects of Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate?▼
Most common in children: appetite loss, insomnia, abdominal pain, emotional instability, vomiting. In adolescents: appetite loss (36%), insomnia (12%), weight loss (9%). Adults: dry mouth (35%), appetite loss (33%), insomnia (27%), headache (26%).
Can I take Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate during pregnancy?▼
Available data have not identified a drug-associated risk of major birth defects and miscarriage. However, animal studies show decreased pup survival and developmental delays at clinically relevant doses.
What are the important warnings for Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate, And Amphetamine Sulfate?▼
High potential for abuse and misuse, which can lead to substance use disorder, including addiction. Sudden cardiac death risk in patients with serious cardiac disease; increased blood pressure/heart rate; psychiatric adverse reactions; growth suppression; seizure threshold lowering; peripheral vasculopathy; serotonin syndrome risk. Contraindicated with known hypersensitivity to amphetamine and MAOI use.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.