Diphenhydramine
Generic Name: diphenhydramine hydrochloride
Brand Names:
Benadryl, ZzzQuil, Sominex, Unisom SleepGels
Diphenhydramine is a first-generation antihistamine used to relieve allergy symptoms, treat motion sickness, and as a short-term sleep aid.
Overview
Diphenhydramine is a first-generation antihistamine used to relieve allergy symptoms, treat motion sickness, and as a short-term sleep aid.
Uses
Allergic rhinitis, urticaria, itching, common cold symptoms, motion sickness, short-term insomnia.
Dosage
Adults: 25–50 mg every 4–6 hours as needed (max 300 mg/day). As sleep aid: 50 mg at bedtime.
Side Effects
Common: Drowsiness, dry mouth, dizziness, constipation, blurred vision.
Interactions
CNS depressants enhanced sedation. MAO inhibitors increased anticholinergic effects.
Warnings
Causes significant drowsiness. Not recommended for older adults. Avoid alcohol.
Pregnancy
Category B — Generally considered safe for occasional use during pregnancy.
Storage
Store at room temperature.
Frequently Asked Questions
What is Diphenhydramine used for?▼
Allergic rhinitis, urticaria, itching, common cold symptoms, motion sickness, short-term insomnia.
What are the side effects of Diphenhydramine?▼
Common: Drowsiness, dry mouth, dizziness, constipation, blurred vision.
Can I take Diphenhydramine during pregnancy?▼
Category B — Generally considered safe for occasional use during pregnancy.
What are the important warnings for Diphenhydramine?▼
Causes significant drowsiness. Not recommended for older adults. Avoid alcohol.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.