Diphenoxylate Hydrochloride And Atropine Sulfate

Generic Name: diphenoxylate hydrochloride and atropine sulfate

Over-the-Counter (OTC)

Brand Names:

Diphenoxylate Hydrochloride And Atropine Sulfate

Diphenoxylate Hydrochloride and Atropine Sulfate is a prescription antidiarrheal medication containing 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate per tablet.

Overview

Diphenoxylate Hydrochloride and Atropine Sulfate is a prescription antidiarrheal medication containing 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate per tablet.

Uses

Indicated as adjunctive therapy in the management of diarrhea in patients 13 years of age and older.

Dosage

Initial adult dosage is 2 tablets four times daily (maximum 20 mg diphenoxylate per day). After initial control, dosage may be reduced. If improvement not seen within 10 days, discontinue use.

Side Effects

Includes respiratory/CNS depression, atropinism, numbness of extremities, euphoria, depression, dizziness, hallucination, urticaria, megacolon, paralytic ileus, tachycardia, urinary retention, flushing, and dry skin/mucous membranes.

Interactions

Alcohol increases CNS depressant effects. Other CNS depressants potentiate effects. MAOIs may precipitate hypertensive crisis.

Warnings

Respiratory/CNS depression in pediatric patients less than 6 years of age. Anticholinergic and opioid toxicities. Dehydration and electrolyte imbalance risk. GI complications with infectious diarrhea. Toxic megacolon in ulcerative colitis. Contraindicated in pediatric patients less than 6 years, diarrhea with C. difficile, known hypersensitivity, and obstructive jaundice.

Pregnancy

Should be used during pregnancy only if anticipated benefit justifies potential fetal risk. Caution with nursing women as metabolites and atropine may be excreted in breast milk.

Storage

Store below 25 degrees C (77 degrees F).

Frequently Asked Questions

What is Diphenoxylate Hydrochloride And Atropine Sulfate used for?

Indicated as adjunctive therapy in the management of diarrhea in patients 13 years of age and older.

What are the side effects of Diphenoxylate Hydrochloride And Atropine Sulfate?

Includes respiratory/CNS depression, atropinism, numbness of extremities, euphoria, depression, dizziness, hallucination, urticaria, megacolon, paralytic ileus, tachycardia, urinary retention, flushing, and dry skin/mucous membranes.

Can I take Diphenoxylate Hydrochloride And Atropine Sulfate during pregnancy?

Should be used during pregnancy only if anticipated benefit justifies potential fetal risk. Caution with nursing women as metabolites and atropine may be excreted in breast milk.

What are the important warnings for Diphenoxylate Hydrochloride And Atropine Sulfate?

Respiratory/CNS depression in pediatric patients less than 6 years of age. Anticholinergic and opioid toxicities. Dehydration and electrolyte imbalance risk. GI complications with infectious diarrhea. Toxic megacolon in ulcerative colitis. Contraindicated in pediatric patients less than 6 years, diarrhea with C. difficile, known hypersensitivity, and obstructive jaundice.

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Medical Disclaimer

This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.