Donepezil Hydrochloride
Generic Name: donepezil hydrochloride
Brand Names:
Donepezil Hydrochloride
Donepezil hydrochloride is a reversible acetylcholinesterase inhibitor available as film-coated tablets in 5 mg and 10 mg strengths for the treatment of Alzheimer's disease.
Overview
Donepezil hydrochloride is a reversible acetylcholinesterase inhibitor available as film-coated tablets in 5 mg and 10 mg strengths for the treatment of Alzheimer's disease.
Uses
Indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's Disease.
Dosage
Mild to moderate disease: 5-10 mg once daily. Moderate to severe disease: 10 mg once daily. Initial dose is 5 mg in the evening before retiring, with advancement to 10 mg only after 4-6 weeks at the lower dose. May be taken with or without food.
Side Effects
Most common adverse reactions include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia. Post-marketing reports include serious conditions like heart block, hepatitis, and convulsions.
Interactions
Cholinesterase inhibitors may interfere with anticholinergic medications and produce synergistic effects with succinylcholine, neuromuscular blocking agents, or cholinergic agonists.
Warnings
Monitor for cholinergic crisis symptoms including bradycardia and heart block. Risk of nausea, vomiting, and gastrointestinal bleeding, particularly with NSAIDs. Potential for seizures, bladder obstruction, and respiratory complications in patients with asthma or pulmonary disease. Contraindicated in known hypersensitivity to donepezil or piperidine derivatives.
Pregnancy
Animal studies showed no teratogenic effects during organogenesis but demonstrated increased stillbirths and reduced offspring survival at clinically relevant doses.
Storage
Store at 68-77 degrees F (20-25 degrees C); excursions permitted to 59-86 degrees F (15-30 degrees C).
Frequently Asked Questions
What is Donepezil Hydrochloride used for?▼
Indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's Disease.
What are the side effects of Donepezil Hydrochloride?▼
Most common adverse reactions include nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia. Post-marketing reports include serious conditions like heart block, hepatitis, and convulsions.
Can I take Donepezil Hydrochloride during pregnancy?▼
Animal studies showed no teratogenic effects during organogenesis but demonstrated increased stillbirths and reduced offspring survival at clinically relevant doses.
What are the important warnings for Donepezil Hydrochloride?▼
Monitor for cholinergic crisis symptoms including bradycardia and heart block. Risk of nausea, vomiting, and gastrointestinal bleeding, particularly with NSAIDs. Potential for seizures, bladder obstruction, and respiratory complications in patients with asthma or pulmonary disease. Contraindicated in known hypersensitivity to donepezil or piperidine derivatives.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.