Doxazosin
Generic Name: doxazosin
Brand Names:
Doxazosin
Doxazosin is a selective alpha-1 adrenergic receptor inhibitor used for the treatment of benign prostatic hyperplasia and hypertension.
Overview
Doxazosin is a selective alpha-1 adrenergic receptor inhibitor used for the treatment of benign prostatic hyperplasia and hypertension.
Uses
Indicated for signs and symptoms of Benign Prostatic Hyperplasia (BPH) and treatment of hypertension.
Dosage
For BPH: initiate at 1 mg daily, titrate at 1-2 week intervals up to maximum 8 mg daily. For hypertension: begin at 1 mg daily, increase as needed to maximum 16 mg daily. Monitor blood pressure for at least 6 hours after initial dose or dose increases.
Side Effects
Common adverse effects include dizziness (15.6-19% incidence), fatigue (8-12%), somnolence (3-5%), hypotension, and edema. Post-marketing reports document priapism, intraoperative floppy iris syndrome, and blood cell count decreases.
Interactions
Strong CYP3A inhibitors may increase doxazosin exposure. PDE-5 inhibitors combined with doxazosin cause additive blood pressure reduction and symptomatic hypotension risks.
Warnings
Risk of postural hypotension with syncope possible. Intraoperative floppy iris syndrome during cataract surgery. Prostate cancer screening recommended. Contraindicated in hypersensitivity to doxazosin, other quinazolines, or any other ingredient.
Frequently Asked Questions
What is Doxazosin used for?▼
Indicated for signs and symptoms of Benign Prostatic Hyperplasia (BPH) and treatment of hypertension.
What are the side effects of Doxazosin?▼
Common adverse effects include dizziness (15.6-19% incidence), fatigue (8-12%), somnolence (3-5%), hypotension, and edema. Post-marketing reports document priapism, intraoperative floppy iris syndrome, and blood cell count decreases.
What are the important warnings for Doxazosin?▼
Risk of postural hypotension with syncope possible. Intraoperative floppy iris syndrome during cataract surgery. Prostate cancer screening recommended. Contraindicated in hypersensitivity to doxazosin, other quinazolines, or any other ingredient.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.