Duloxetine Hydrochloride
Generic Name: duloxetine hydrochloride
Brand Names:
Duloxetine Delayed-release
Duloxetine hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI) available as delayed-release capsules for multiple indications.
Overview
Duloxetine hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI) available as delayed-release capsules for multiple indications.
Uses
Approved for major depressive disorder in adults, generalized anxiety disorder in adults and pediatric patients 7+, diabetic peripheral neuropathic pain, fibromyalgia in adults and pediatric patients 13+, and chronic musculoskeletal pain in adults.
Dosage
Take once daily with or without food; swallow whole without crushing. Starting doses range from 30-60 mg/day depending on indication, with target doses typically 60 mg/day and maximum doses up to 120 mg/day.
Side Effects
Most common: nausea (23%), dry mouth (13%), somnolence (10%), constipation (9%), decreased appetite (7%), and hyperhidrosis (6%).
Interactions
Contraindicated with MAOIs intended to treat psychiatric disorders due to increased risk of serotonin syndrome.
Warnings
BOXED WARNING: Suicidal thoughts and behaviors - antidepressants increased the risk in children, adolescents, and young adults. Includes hepatotoxicity warnings, orthostatic hypotension risks, serotonin syndrome alerts, bleeding risk increases, severe skin reactions, and discontinuation syndrome concerns.
Frequently Asked Questions
What is Duloxetine Hydrochloride used for?▼
Approved for major depressive disorder in adults, generalized anxiety disorder in adults and pediatric patients 7+, diabetic peripheral neuropathic pain, fibromyalgia in adults and pediatric patients 13+, and chronic musculoskeletal pain in adults.
What are the side effects of Duloxetine Hydrochloride?▼
Most common: nausea (23%), dry mouth (13%), somnolence (10%), constipation (9%), decreased appetite (7%), and hyperhidrosis (6%).
What are the important warnings for Duloxetine Hydrochloride?▼
BOXED WARNING: Suicidal thoughts and behaviors - antidepressants increased the risk in children, adolescents, and young adults. Includes hepatotoxicity warnings, orthostatic hypotension risks, serotonin syndrome alerts, bleeding risk increases, severe skin reactions, and discontinuation syndrome concerns.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.