Entacapone
Generic Name: entacapone
Brand Names:
Entacapone
Entacapone is a COMT inhibitor available as 200 mg tablets, used as an adjunct to levodopa and carbidopa in the treatment of Parkinson's disease.
Overview
Entacapone is a COMT inhibitor available as 200 mg tablets, used as an adjunct to levodopa and carbidopa in the treatment of Parkinson's disease.
Uses
Indicated as an adjunct to levodopa and carbidopa to treat end-of-dose wearing-off in patients with Parkinson's disease.
Dosage
The recommended dose is one 200 mg tablet administered concomitantly with each levodopa and carbidopa dose to a maximum of 8 times daily (200 mg x 8 = 1,600 mg per day).
Side Effects
Common adverse events include dyskinesia, urine discoloration, diarrhea, nausea, hyperkinesia, abdominal pain, vomiting, and dry mouth.
Interactions
Notable interaction with warfarin; monitoring of INR is recommended when entacapone treatment is initiated or when the dose is increased.
Warnings
Includes cautions about suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living. Contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
Frequently Asked Questions
What is Entacapone used for?▼
Indicated as an adjunct to levodopa and carbidopa to treat end-of-dose wearing-off in patients with Parkinson's disease.
What are the side effects of Entacapone?▼
Common adverse events include dyskinesia, urine discoloration, diarrhea, nausea, hyperkinesia, abdominal pain, vomiting, and dry mouth.
What are the important warnings for Entacapone?▼
Includes cautions about suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living. Contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.