Eplerenone
Generic Name: eplerenone
Brand Names:
Eplerenone
Eplerenone is a prescription mineralocorticoid receptor antagonist available as film-coated tablets in 25 mg and 50 mg strengths.
Overview
Eplerenone is a prescription mineralocorticoid receptor antagonist available as film-coated tablets in 25 mg and 50 mg strengths.
Uses
Indicated for improving survival in stable patients with symptomatic heart failure with reduced ejection fraction following acute myocardial infarction, and treating hypertension to reduce cardiovascular event risk.
Dosage
For heart failure post-MI: initiate 25 mg daily, titrate to 50 mg daily within 4 weeks as tolerated. For hypertension: 50 mg daily, increase to 50 mg twice daily if needed. Monitor serum potassium before starting and periodically thereafter.
Side Effects
Most common reactions include hyperkalemia and increased creatinine in heart failure patients. Gynecomastia and vaginal bleeding reported in hypertension studies. Postmarketing reports include angioneurotic edema and rash.
Interactions
CYP3A inhibitors increase exposure; do not exceed 25 mg daily with moderate inhibitors. ACE inhibitors and ARBs increase hyperkalemia risk. NSAIDs may reduce antihypertensive effect and cause severe hyperkalemia.
Warnings
Hyperkalemia risk is higher in patients with impaired renal function, proteinuria, diabetes and those taking ACE inhibitors, ARBs, or NSAIDs. Contraindicated when serum potassium greater than 5.5 mEq/L, creatinine clearance 30 mL/min or less, or with strong CYP3A inhibitors.
Pregnancy
Limited human data. Animal studies showed no teratogenic effects at exposures 31-32 times the human dose.
Storage
Store at 25 degrees C (77 degrees F) with excursions permitted between 15-30 degrees C.
Frequently Asked Questions
What is Eplerenone used for?▼
Indicated for improving survival in stable patients with symptomatic heart failure with reduced ejection fraction following acute myocardial infarction, and treating hypertension to reduce cardiovascular event risk.
What are the side effects of Eplerenone?▼
Most common reactions include hyperkalemia and increased creatinine in heart failure patients. Gynecomastia and vaginal bleeding reported in hypertension studies. Postmarketing reports include angioneurotic edema and rash.
Can I take Eplerenone during pregnancy?▼
Limited human data. Animal studies showed no teratogenic effects at exposures 31-32 times the human dose.
What are the important warnings for Eplerenone?▼
Hyperkalemia risk is higher in patients with impaired renal function, proteinuria, diabetes and those taking ACE inhibitors, ARBs, or NSAIDs. Contraindicated when serum potassium greater than 5.5 mEq/L, creatinine clearance 30 mL/min or less, or with strong CYP3A inhibitors.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.