Erythromycin Ethylsuccinate
Generic Name: erythromycin ethylsuccinate
Brand Names:
Erythromycin Ethylsuccinate
Erythromycin ethylsuccinate oral suspension is a macrolide antibiotic available in 200 mg/5 mL and 400 mg/5 mL formulations with cherry flavor for pediatric and adult use.
Overview
Erythromycin ethylsuccinate oral suspension is a macrolide antibiotic available in 200 mg/5 mL and 400 mg/5 mL formulations with cherry flavor for pediatric and adult use.
Uses
Treatment of infections caused by susceptible organisms including upper/lower respiratory tract infections, pertussis, skin infections, diphtheria, syphilis, chlamydia infections, and pelvic inflammatory disease; also used for rheumatic fever prophylaxis.
Dosage
Children: 30-50 mg/kg/day in divided doses every 6 hours; Adults: 400 mg every 6 hours, up to 4 g daily. Doses vary by infection type and severity, with specific regimens for streptococcal infections (10 days minimum) and other conditions.
Side Effects
Most common: gastrointestinal effects including nausea, vomiting, abdominal pain, diarrhea. Rare: hepatic dysfunction, pseudomembranous colitis, QT prolongation, arrhythmias, allergic reactions, Stevens-Johnson syndrome, pancreatitis, hearing loss.
Interactions
Significant interactions with theophylline, verapamil, digoxin, oral anticoagulants, benzodiazepines, HMG-CoA reductase inhibitors, sildenafil, cyclosporine, carbamazepine, colchicine, and multiple CYP3A4-metabolized drugs.
Warnings
Hepatotoxicity, QT prolongation and arrhythmia risk, syphilis in pregnancy concerns, Clostridium difficile-associated diarrhea potential, serious drug interactions with CYP3A4 substrates including statins, colchicine, and ergot derivatives. Contraindicated with hypersensitivity to erythromycin; concurrent use with terfenadine, astemizole, pimozide, cisapride, or extensively metabolized statins.
Pregnancy
Animal studies show no teratogenicity or embryotoxicity at doses up to 3 times maximum human dose; however, erythromycin may not adequately prevent congenital syphilis. Erythromycin crosses placental barrier with low fetal levels and is excreted in human milk.
Storage
Store below 86F (30C) prior to reconstitution; after mixing, store at or below 77F (25C) and use within 35 days.
Frequently Asked Questions
What is Erythromycin Ethylsuccinate used for?▼
Treatment of infections caused by susceptible organisms including upper/lower respiratory tract infections, pertussis, skin infections, diphtheria, syphilis, chlamydia infections, and pelvic inflammatory disease; also used for rheumatic fever prophylaxis.
What are the side effects of Erythromycin Ethylsuccinate?▼
Most common: gastrointestinal effects including nausea, vomiting, abdominal pain, diarrhea. Rare: hepatic dysfunction, pseudomembranous colitis, QT prolongation, arrhythmias, allergic reactions, Stevens-Johnson syndrome, pancreatitis, hearing loss.
Can I take Erythromycin Ethylsuccinate during pregnancy?▼
Animal studies show no teratogenicity or embryotoxicity at doses up to 3 times maximum human dose; however, erythromycin may not adequately prevent congenital syphilis. Erythromycin crosses placental barrier with low fetal levels and is excreted in human milk.
What are the important warnings for Erythromycin Ethylsuccinate?▼
Hepatotoxicity, QT prolongation and arrhythmia risk, syphilis in pregnancy concerns, Clostridium difficile-associated diarrhea potential, serious drug interactions with CYP3A4 substrates including statins, colchicine, and ergot derivatives. Contraindicated with hypersensitivity to erythromycin; concurrent use with terfenadine, astemizole, pimozide, cisapride, or extensively metabolized statins.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.