Eslicarbazepine Acetate
Generic Name: eslicarbazepine acetate
Brand Names:
Eslicarbazepine Acetate
Eslicarbazepine acetate is a dibenz[b,f]azepine-5-carboxamide derivative available as white to off-white tablets in strengths of 200 mg, 400 mg, 600 mg, and 800 mg.
Overview
Eslicarbazepine acetate is a dibenz[b,f]azepine-5-carboxamide derivative available as white to off-white tablets in strengths of 200 mg, 400 mg, 600 mg, and 800 mg.
Uses
Eslicarbazepine acetate tablets are indicated for treating partial-onset seizures in patients 4 years of age and older.
Dosage
Adult initial dose: 400 mg once daily, increasing weekly by 400-600 mg to maintenance of 800-1,600 mg daily. Pediatric dosing is weight-based. Reduce by 50% in moderate/severe renal impairment.
Side Effects
Most common: dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, and tremor.
Interactions
Carbamazepine reduces eslicarbazepine levels; enzyme-inducing AEDs may require higher doses. Inhibits CYP2C19 and may induce CYP3A4. Reduces hormonal contraceptive effectiveness.
Warnings
Monitor for suicidal behavior, serious dermatologic reactions (SJS/TEN), DRESS, anaphylaxis, hyponatremia, neurological effects, liver injury, and hematologic abnormalities. Contraindicated in patients with hypersensitivity to eslicarbazepine acetate or oxcarbazepine.
Pregnancy
Animal studies showed developmental toxicity including malformations and fetal growth retardation. Limited human pregnancy data. Eslicarbazepine is present in human milk; effects on breastfed infants unknown.
Storage
Store at 20C to 25C (68F to 77F); excursions permitted 15C to 30C (59F to 86F).
Frequently Asked Questions
What is Eslicarbazepine Acetate used for?▼
Eslicarbazepine acetate tablets are indicated for treating partial-onset seizures in patients 4 years of age and older.
What are the side effects of Eslicarbazepine Acetate?▼
Most common: dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, and tremor.
Can I take Eslicarbazepine Acetate during pregnancy?▼
Animal studies showed developmental toxicity including malformations and fetal growth retardation. Limited human pregnancy data. Eslicarbazepine is present in human milk; effects on breastfed infants unknown.
What are the important warnings for Eslicarbazepine Acetate?▼
Monitor for suicidal behavior, serious dermatologic reactions (SJS/TEN), DRESS, anaphylaxis, hyponatremia, neurological effects, liver injury, and hematologic abnormalities. Contraindicated in patients with hypersensitivity to eslicarbazepine acetate or oxcarbazepine.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.