Esmolol Hydrochloride
Generic Name: esmolol hydrochloride
Brand Names:
Esmolol Hydrochloride
Esmolol hydrochloride is a beta-1 selective adrenergic receptor blocker with rapid onset and approximately 9 minute elimination half-life, administered intravenously.
Overview
Esmolol hydrochloride is a beta-1 selective adrenergic receptor blocker with rapid onset and approximately 9 minute elimination half-life, administered intravenously.
Uses
Short-term IV treatment for supraventricular tachycardia rate control and perioperative tachycardia/hypertension management.
Dosage
IV infusion: 500 mcg/kg loading dose over 1 min, then 50-200 mcg/kg/min maintenance; titrate at 4-minute or greater intervals based on response.
Side Effects
Most common: symptomatic hypotension (12%), asymptomatic hypotension (12%), infusion site reactions (8%), nausea (7%).
Interactions
Digoxin increases bradycardia risk; anticholinesterases prolong neuromuscular blockade; sympathomimetics counteract effects; avoid vasoconstrictive agents.
Warnings
Risk of hypotension, bradycardia, cardiac failure; masks hypoglycemia symptoms; risk of unopposed alpha-agonism in pheochromocytoma. Contraindicated in severe sinus bradycardia, heart block greater than 1st degree, sick sinus syndrome, decompensated heart failure, cardiogenic shock.
Pregnancy
Esmolol hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Unknown excretion in breast milk.
Storage
Store at 20-25C, protect from freezing and excessive heat; use within 24 hours after withdrawal from bag.
Frequently Asked Questions
What is Esmolol Hydrochloride used for?▼
Short-term IV treatment for supraventricular tachycardia rate control and perioperative tachycardia/hypertension management.
What are the side effects of Esmolol Hydrochloride?▼
Most common: symptomatic hypotension (12%), asymptomatic hypotension (12%), infusion site reactions (8%), nausea (7%).
Can I take Esmolol Hydrochloride during pregnancy?▼
Esmolol hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Unknown excretion in breast milk.
What are the important warnings for Esmolol Hydrochloride?▼
Risk of hypotension, bradycardia, cardiac failure; masks hypoglycemia symptoms; risk of unopposed alpha-agonism in pheochromocytoma. Contraindicated in severe sinus bradycardia, heart block greater than 1st degree, sick sinus syndrome, decompensated heart failure, cardiogenic shock.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.