Estradiol
Generic Name: estradiol
Brand Names:
Menostar
Menostar is a transdermal estradiol system delivering 14 mcg per day, comprised of three layers including a polyethylene film, acrylate adhesive matrix, and protective liner.
Overview
Menostar is a transdermal estradiol system delivering 14 mcg per day, comprised of three layers including a polyethylene film, acrylate adhesive matrix, and protective liner.
Uses
Prevention of postmenopausal osteoporosis. Non-estrogen medications should be considered first; estrogen therapy reserved for women at significant osteoporosis risk.
Dosage
Apply one Menostar patch weekly to clean, dry lower abdomen or upper buttock. Rotate application sites with at least one-week intervals between same-site reapplication.
Side Effects
Most common: upper respiratory tract infections, pain, arthralgia, and leukorrhea. Others include application site reactions, breast pain, cervical polyps.
Interactions
CYP3A4 inducers (St. John's wort, phenobarbital, carbamazepine, rifampin) may reduce estrogen levels. CYP3A4 inhibitors may increase estrogen concentrations.
Warnings
WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER. Unopposed estrogens increase endometrial cancer risk. Do not use for cardiovascular disease or dementia prevention. Increased risks of stroke, DVT, PE, MI, breast cancer reported. Contraindicated with undiagnosed abnormal genital bleeding, breast cancer history, estrogen-dependent neoplasia, active/history of DVT/PE.
Pregnancy
Not indicated for pregnancy. Estrogens are present in human milk and can reduce milk production.
Storage
Store at 68-77F (20-25C). Do not store above 86F. Keep in protective pouch until use. Discard used patches in childproof container.
Frequently Asked Questions
What is Estradiol used for?▼
Prevention of postmenopausal osteoporosis. Non-estrogen medications should be considered first; estrogen therapy reserved for women at significant osteoporosis risk.
What are the side effects of Estradiol?▼
Most common: upper respiratory tract infections, pain, arthralgia, and leukorrhea. Others include application site reactions, breast pain, cervical polyps.
Can I take Estradiol during pregnancy?▼
Not indicated for pregnancy. Estrogens are present in human milk and can reduce milk production.
What are the important warnings for Estradiol?▼
WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, PROBABLE DEMENTIA and BREAST CANCER. Unopposed estrogens increase endometrial cancer risk. Do not use for cardiovascular disease or dementia prevention. Increased risks of stroke, DVT, PE, MI, breast cancer reported. Contraindicated with undiagnosed abnormal genital bleeding, breast cancer history, estrogen-dependent neoplasia, active/history of DVT/PE.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.