Ethosuximide
Generic Name: ethosuximide
Brand Names:
Ethosuximide
Ethosuximide is an anticonvulsant succinimide containing 250 mg ethosuximide per 5 mL oral solution with cherry-raspberry flavoring.
Overview
Ethosuximide is an anticonvulsant succinimide containing 250 mg ethosuximide per 5 mL oral solution with cherry-raspberry flavoring.
Uses
Indicated for the control of absence (petit mal) epilepsy.
Dosage
Initial dose ages 3-6: one teaspoonful (250 mg) daily; ages 6 and older: 2 teaspoonfuls (500 mg) daily. Increase by 250 mg every 4-7 days. Optimal pediatric dose: 20 mg/kg/day. Maximum: 1.5 g daily under physician supervision.
Side Effects
Common: nausea, vomiting, gastric upset, diarrhea, weight loss. Serious: blood dyscrasias, Stevens-Johnson syndrome, DRESS, hematologic complications including leukopenia and thrombocytopenia. Neurologic: drowsiness, headache, dizziness, ataxia.
Interactions
Ethosuximide may elevate phenytoin serum levels; valproic acid reported to both increase and decrease ethosuximide levels. Periodic serum level monitoring recommended.
Warnings
Blood dyscrasias including fatal outcomes reported; periodic blood counts advised. Antiepileptic drugs increase risk of suicidal thoughts or behavior. Stevens-Johnson syndrome and DRESS reported. Should not be used in patients with a history of hypersensitivity to succinimides.
Pregnancy
Ethosuximide crosses placenta; birth defects reported. Anticonvulsant drugs should not be discontinued in patients preventing major seizures due to status epilepticus risk. Drug excreted in breast milk; use only if benefits outweigh risks.
Storage
Store at 20 to 25C (68 to 77F). Preserve in tight containers. Protect from freezing and light.
Frequently Asked Questions
What is Ethosuximide used for?▼
Indicated for the control of absence (petit mal) epilepsy.
What are the side effects of Ethosuximide?▼
Common: nausea, vomiting, gastric upset, diarrhea, weight loss. Serious: blood dyscrasias, Stevens-Johnson syndrome, DRESS, hematologic complications including leukopenia and thrombocytopenia. Neurologic: drowsiness, headache, dizziness, ataxia.
Can I take Ethosuximide during pregnancy?▼
Ethosuximide crosses placenta; birth defects reported. Anticonvulsant drugs should not be discontinued in patients preventing major seizures due to status epilepticus risk. Drug excreted in breast milk; use only if benefits outweigh risks.
What are the important warnings for Ethosuximide?▼
Blood dyscrasias including fatal outcomes reported; periodic blood counts advised. Antiepileptic drugs increase risk of suicidal thoughts or behavior. Stevens-Johnson syndrome and DRESS reported. Should not be used in patients with a history of hypersensitivity to succinimides.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.