Etodolac
Generic Name: etodolac
Brand Names:
Etodolac
Etodolac is a member of the pyranocarboxylic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Film coated tablets contain 400 mg or 500 mg of etodolac.
Overview
Etodolac is a member of the pyranocarboxylic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Film coated tablets contain 400 mg or 500 mg of etodolac.
Uses
Indicated for acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, and for management of acute pain.
Dosage
For acute pain: recommended total daily dose up to 1000 mg, given as 200-400 mg every 6 to 8 hours. For osteoarthritis/rheumatoid arthritis: starting dose 300 mg two to three times daily, or 400-500 mg twice daily. A lower dose of 600 mg/day may suffice for long-term use.
Side Effects
Most frequently reported: gastrointestinal experiences including abdominal pain, constipation, diarrhea, dyspepsia, heartburn, nausea, GI ulcers, vomiting. Other events: abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, rashes, tinnitus.
Interactions
ACE-inhibitors: NSAIDs may diminish antihypertensive effect. Aspirin: not generally recommended. Cyclosporine, Digoxin, Methotrexate: may cause elevated serum levels. Diuretics: can reduce natriuretic effect. Lithium: NSAIDs may elevate plasma lithium levels. Warfarin: synergistic effects on GI bleeding.
Warnings
Cardiovascular: NSAIDs increase risk of serious cardiovascular thrombotic events including myocardial infarction and stroke. Contraindicated after CABG surgery. Gastrointestinal: Can cause serious GI adverse events including bleeding, ulceration, and perforation. Avoid use at about 30 weeks gestation and later. Contraindicated with known hypersensitivity to etodolac or asthma/urticaria after aspirin or other NSAIDs.
Pregnancy
NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction. Avoid use at about 30 weeks gestation and later. Trace amounts reported in human milk.
Storage
Store at 20C to 25C (68F to 77F) in original container. Dispense in light-resistant container.
Frequently Asked Questions
What is Etodolac used for?▼
Indicated for acute and long-term management of signs and symptoms of osteoarthritis and rheumatoid arthritis, and for management of acute pain.
What are the side effects of Etodolac?▼
Most frequently reported: gastrointestinal experiences including abdominal pain, constipation, diarrhea, dyspepsia, heartburn, nausea, GI ulcers, vomiting. Other events: abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, rashes, tinnitus.
Can I take Etodolac during pregnancy?▼
NSAIDs can cause premature closure of fetal ductus arteriosus and fetal renal dysfunction. Avoid use at about 30 weeks gestation and later. Trace amounts reported in human milk.
What are the important warnings for Etodolac?▼
Cardiovascular: NSAIDs increase risk of serious cardiovascular thrombotic events including myocardial infarction and stroke. Contraindicated after CABG surgery. Gastrointestinal: Can cause serious GI adverse events including bleeding, ulceration, and perforation. Avoid use at about 30 weeks gestation and later. Contraindicated with known hypersensitivity to etodolac or asthma/urticaria after aspirin or other NSAIDs.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.