Etoposide
Generic Name: etoposide
Brand Names:
Avopef
Etoposide is a topoisomerase inhibitor available as a sterile, clear, colorless to light yellow liquid containing 20 mg/mL etoposide for IV administration.
Overview
Etoposide is a topoisomerase inhibitor available as a sterile, clear, colorless to light yellow liquid containing 20 mg/mL etoposide for IV administration.
Uses
Indicated in combination with chemotherapy/immunotherapy for refractory testicular cancer and small cell lung cancer.
Dosage
Testicular cancer: 50-100 mg/m2 daily Days 1-5, or 100 mg/m2 Days 1,3,5. Small cell lung cancer: 35 mg/m2 daily Days 1-4, or 50 mg/m2 Days 1-5. Dilute to 0.2-0.4 mg/mL, infuse over 30-60 minutes.
Side Effects
Most common: myelosuppression, hypersensitivity, nausea/vomiting, alopecia. Serious: acute leukemia, anaphylaxis, tissue necrosis, Stevens-Johnson syndrome.
Interactions
Avoid strong CYP3A inhibitors and inducers. Monitor INR with warfarin; may increase vitamin K antagonist effects.
Warnings
Can cause severe myelosuppression resulting in infection or bleeding. Do not administer to patients with absolute neutrophil counts less than 500 cells/mm3 or platelets less than 50,000 cells/mm3. Risk of anaphylaxis, extravasation necrosis, and secondary leukemia. Contraindicated with hypersensitivity to etoposide.
Pregnancy
Can cause fetal harm. Animal studies showed embryo-fetal mortality and structural abnormalities. Females should use contraception during and 6 months after treatment. Do not breastfeed during treatment and 1 week after last dose.
Storage
Store at 20-25C (68-77F). After first use, store in original carton for up to 28 days. Hazardous drug; follow special handling procedures.
Frequently Asked Questions
What is Etoposide used for?▼
Indicated in combination with chemotherapy/immunotherapy for refractory testicular cancer and small cell lung cancer.
What are the side effects of Etoposide?▼
Most common: myelosuppression, hypersensitivity, nausea/vomiting, alopecia. Serious: acute leukemia, anaphylaxis, tissue necrosis, Stevens-Johnson syndrome.
Can I take Etoposide during pregnancy?▼
Can cause fetal harm. Animal studies showed embryo-fetal mortality and structural abnormalities. Females should use contraception during and 6 months after treatment. Do not breastfeed during treatment and 1 week after last dose.
What are the important warnings for Etoposide?▼
Can cause severe myelosuppression resulting in infection or bleeding. Do not administer to patients with absolute neutrophil counts less than 500 cells/mm3 or platelets less than 50,000 cells/mm3. Risk of anaphylaxis, extravasation necrosis, and secondary leukemia. Contraindicated with hypersensitivity to etoposide.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.