Ezetimibe And Simvastatin
Generic Name: ezetimibe and simvastatin
Brand Names:
Ezetimibe And Simvastatin
Ezetimibe and simvastatin tablets contain ezetimibe (dietary cholesterol absorption inhibitor) and simvastatin (HMG-CoA reductase inhibitor). Available in strengths of 10/10, 10/20, 10/40, and 10/80 mg.
Overview
Ezetimibe and simvastatin tablets contain ezetimibe (dietary cholesterol absorption inhibitor) and simvastatin (HMG-CoA reductase inhibitor). Available in strengths of 10/10, 10/20, 10/40, and 10/80 mg.
Uses
As an adjunct to diet to reduce elevated low density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia and pediatric patients aged 10 and older with heterozygous familial hypercholesterolemia.
Dosage
Take ezetimibe and simvastatin orally once daily in the evening with or without food. Maximum recommended dosage is 10/40 mg daily; 10/80 mg restricted to chronic users without muscle toxicity.
Side Effects
Common adverse effects (2% or greater and greater than placebo) include headache (5.8%), increased ALT (3.7%), myalgia (3.6%), upper respiratory tract infection (3.6%), and diarrhea (2.8%).
Interactions
Concomitant use of strong CYP3A4 inhibitors with ezetimibe and simvastatin is contraindicated. Dose adjustments required for certain medications.
Warnings
Risk of myopathy and rhabdomyolysis, particularly with higher doses. Temporarily discontinue in patients experiencing acute serious conditions at high risk of renal failure. Contraindicated with strong CYP3A4 inhibitors, cyclosporine, danazol, or gemfibrozil. Also contraindicated in acute liver failure or decompensated cirrhosis.
Pregnancy
Discontinue when pregnancy is recognized. The drug decreases cholesterol synthesis and may cause fetal harm. Breastfeeding not recommended during treatment.
Frequently Asked Questions
What is Ezetimibe And Simvastatin used for?▼
As an adjunct to diet to reduce elevated low density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia and pediatric patients aged 10 and older with heterozygous familial hypercholesterolemia.
What are the side effects of Ezetimibe And Simvastatin?▼
Common adverse effects (2% or greater and greater than placebo) include headache (5.8%), increased ALT (3.7%), myalgia (3.6%), upper respiratory tract infection (3.6%), and diarrhea (2.8%).
Can I take Ezetimibe And Simvastatin during pregnancy?▼
Discontinue when pregnancy is recognized. The drug decreases cholesterol synthesis and may cause fetal harm. Breastfeeding not recommended during treatment.
What are the important warnings for Ezetimibe And Simvastatin?▼
Risk of myopathy and rhabdomyolysis, particularly with higher doses. Temporarily discontinue in patients experiencing acute serious conditions at high risk of renal failure. Contraindicated with strong CYP3A4 inhibitors, cyclosporine, danazol, or gemfibrozil. Also contraindicated in acute liver failure or decompensated cirrhosis.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.