Fluoxetine
Generic Name: fluoxetine
Brand Names:
Fluoxetine
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) available as capsules in 10 mg, 20 mg, and 40 mg strengths.
Overview
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) available as capsules in 10 mg, 20 mg, and 40 mg strengths.
Uses
Treats Major Depressive Disorder, Obsessive Compulsive Disorder, Bulimia Nervosa, and Panic Disorder. In combination with olanzapine, indicated for acute depressive episodes associated with Bipolar I Disorder and treatment-resistant depression.
Dosage
Adults: MDD 20 mg/day initially; OCD 20 mg/day initially; Bulimia 60 mg/day; Panic Disorder 10 mg/day initially. Pediatric dosing varies by indication (10-20 mg/day). Maximum dose typically 80 mg/day for monotherapy.
Side Effects
Common reactions include nausea (22%), insomnia (19%), nervousness (13%), anxiety (12%), somnolence (12%), tremor (9%), diarrhea (11%), and decreased libido (4%).
Interactions
Interactions with MAOIs, linezolid, methylene blue, and drugs affecting coagulation. Contraindicated with pimozide and thioridazine due to QT prolongation risk.
Warnings
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults. Monitor closely for worsening and suicidal emergence. Risk of serotonin syndrome with MAOIs. Bleeding risk with NSAIDs/anticoagulants. QT prolongation possible. Contraindicated with MAOIs, pimozide, and thioridazine.
Frequently Asked Questions
What is Fluoxetine used for?▼
Treats Major Depressive Disorder, Obsessive Compulsive Disorder, Bulimia Nervosa, and Panic Disorder. In combination with olanzapine, indicated for acute depressive episodes associated with Bipolar I Disorder and treatment-resistant depression.
What are the side effects of Fluoxetine?▼
Common reactions include nausea (22%), insomnia (19%), nervousness (13%), anxiety (12%), somnolence (12%), tremor (9%), diarrhea (11%), and decreased libido (4%).
What are the important warnings for Fluoxetine?▼
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults. Monitor closely for worsening and suicidal emergence. Risk of serotonin syndrome with MAOIs. Bleeding risk with NSAIDs/anticoagulants. QT prolongation possible. Contraindicated with MAOIs, pimozide, and thioridazine.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.