Fluoxetine Hydrochloride
Generic Name: fluoxetine hydrochloride
Brand Names:
Fluoxetine
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant available in capsule form for the treatment of major depressive disorder, obsessive compulsive disorder, bulimia nervosa, and panic disorder.
Overview
Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant available in capsule form for the treatment of major depressive disorder, obsessive compulsive disorder, bulimia nervosa, and panic disorder.
Uses
Treatment of Major Depressive Disorder, Obsessive Compulsive Disorder, Bulimia Nervosa, and Panic Disorder. In combination with olanzapine for acute depressive episodes associated with Bipolar I Disorder and treatment-resistant depression.
Dosage
Adults: 20 mg/day initial dose for MDD/OCD, 60 mg/day for Bulimia, 10 mg/day initial for Panic. Pediatric dosing varies by indication. Maximum dose typically 80 mg/day.
Side Effects
Common side effects include nausea (22%), insomnia (19%), nervousness (13%), and tremor (9%). Sexual dysfunction, weight loss, and allergic reactions reported. Serious reactions include serotonin syndrome and QT prolongation.
Interactions
Risk of serotonin syndrome with serotonergic agents (triptans, TCAs, tramadol, lithium, St. John's Wort). QT interval prolongation with certain antipsychotics and antibiotics. CYP2D6 inhibition affects TCA metabolism.
Warnings
Black box warning: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Risk of serotonin syndrome with other serotonergic agents, QT prolongation, bleeding risk, hyponatremia, and seizures. Do not use with MAOIs or within specified washout periods. Avoid pimozide and thioridazine due to QT prolongation risk.
Frequently Asked Questions
What is Fluoxetine Hydrochloride used for?▼
Treatment of Major Depressive Disorder, Obsessive Compulsive Disorder, Bulimia Nervosa, and Panic Disorder. In combination with olanzapine for acute depressive episodes associated with Bipolar I Disorder and treatment-resistant depression.
What are the side effects of Fluoxetine Hydrochloride?▼
Common side effects include nausea (22%), insomnia (19%), nervousness (13%), and tremor (9%). Sexual dysfunction, weight loss, and allergic reactions reported. Serious reactions include serotonin syndrome and QT prolongation.
What are the important warnings for Fluoxetine Hydrochloride?▼
Black box warning: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. Risk of serotonin syndrome with other serotonergic agents, QT prolongation, bleeding risk, hyponatremia, and seizures. Do not use with MAOIs or within specified washout periods. Avoid pimozide and thioridazine due to QT prolongation risk.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.