Fulvestrant
Generic Name: fulvestrant
Brand Names:
Fulvestrant
Fulvestrant is an estrogen receptor antagonist indicated for hormone receptor-positive, HER2-negative advanced breast cancer in postmenopausal women, available as monotherapy or in combination with CDK4/6 inhibitors.
Overview
Fulvestrant is an estrogen receptor antagonist indicated for hormone receptor-positive, HER2-negative advanced breast cancer in postmenopausal women, available as monotherapy or in combination with CDK4/6 inhibitors.
Uses
HR-positive, HER2-negative advanced breast cancer in postmenopausal women, either treatment-naive or with progression after endocrine therapy. Also indicated in combination with ribociclib, palbociclib, or abemaciclib.
Dosage
500 mg administered intramuscularly as two 5 mL injections into buttocks on Days 1, 15, 29, and monthly thereafter. Reduce to 250 mg for moderate hepatic impairment.
Side Effects
Most common (5% or greater): injection site pain, nausea, bone pain, arthralgia, headache, back pain, fatigue. In combination studies: neutropenia, leukopenia, infections, diarrhea, stomatitis. Hepatic enzyme elevation reported.
Warnings
Risk of bleeding with anticoagulants. Caution with dorsogluteal injection due to sciatic nerve proximity. Embryo-fetal toxicity risk. Can interfere with estradiol immunoassay measurements. Dose reduction required for hepatic impairment. Contraindicated in patients with known hypersensitivity to fulvestrant.
Pregnancy
Can cause fetal harm. Based on animal studies, administration during organogenesis resulted in embryo-fetal toxicity at doses significantly less than human maximum recommended dose. Advise females of reproductive potential to use effective contraception during treatment and for one year after final dose.
Frequently Asked Questions
What is Fulvestrant used for?▼
HR-positive, HER2-negative advanced breast cancer in postmenopausal women, either treatment-naive or with progression after endocrine therapy. Also indicated in combination with ribociclib, palbociclib, or abemaciclib.
What are the side effects of Fulvestrant?▼
Most common (5% or greater): injection site pain, nausea, bone pain, arthralgia, headache, back pain, fatigue. In combination studies: neutropenia, leukopenia, infections, diarrhea, stomatitis. Hepatic enzyme elevation reported.
Can I take Fulvestrant during pregnancy?▼
Can cause fetal harm. Based on animal studies, administration during organogenesis resulted in embryo-fetal toxicity at doses significantly less than human maximum recommended dose. Advise females of reproductive potential to use effective contraception during treatment and for one year after final dose.
What are the important warnings for Fulvestrant?▼
Risk of bleeding with anticoagulants. Caution with dorsogluteal injection due to sciatic nerve proximity. Embryo-fetal toxicity risk. Can interfere with estradiol immunoassay measurements. Dose reduction required for hepatic impairment. Contraindicated in patients with known hypersensitivity to fulvestrant.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.