I.v. Fat Emulsion

Generic Name: i.v. fat emulsion

Lipid Emulsion [EPC]Over-the-Counter (OTC)

Brand Names:

Intralipid

I.V. fat emulsion is a sterile, non-pyrogenic lipid emulsion containing soybean oil with egg phospholipids and glycerin, used as a source of calories and essential fatty acids for parenteral nutrition.

Overview

Uses

Source of calories and essential fatty acids for adults and pediatric patients requiring parenteral nutrition. Also used for essential fatty acid deficiency (EFAD) prevention.

Dosage

Intravenous infusion into peripheral or central vein. Dosing depends on age and clinical status: 0.5-3 g/kg/day for neonates, 1-2.5 g/kg/day for older patients.

Side Effects

Most common in adults: nausea, vomiting, pyrexia. In pediatric patients: anemia, vomiting, increased gamma-glutamyltransferase, cholestasis.

Interactions

Vitamin K antagonists (warfarin): anticoagulant activity may be counteracted. Increase monitoring of coagulation parameters.

Warnings

Risk of clinical decompensation with rapid infusion in neonates/infants. Risks include parenteral nutrition-associated liver disease, hypersensitivity reactions, infections, fat overload syndrome, hypertriglyceridemia, aluminum toxicity. Contraindicated in known hypersensitivity to egg, soybean, or peanut, and severe hypertriglyceridemia.

Pregnancy

Not expected to cause birth defects at recommended doses. Severe malnutrition in pregnancy warrants parenteral nutrition consideration.

Storage

Store below 25 degrees C (77 degrees F). Do not freeze. Single-dose containers: use immediately or refrigerate at 2-8 degrees C for max 24 hours.

Frequently Asked Questions

What is I.v. Fat Emulsion used for?▼

Source of calories and essential fatty acids for adults and pediatric patients requiring parenteral nutrition. Also used for essential fatty acid deficiency (EFAD) prevention.

What are the side effects of I.v. Fat Emulsion?▼

Most common in adults: nausea, vomiting, pyrexia. In pediatric patients: anemia, vomiting, increased gamma-glutamyltransferase, cholestasis.

Can I take I.v. Fat Emulsion during pregnancy?▼

Not expected to cause birth defects at recommended doses. Severe malnutrition in pregnancy warrants parenteral nutrition consideration.

What are the important warnings for I.v. Fat Emulsion?▼

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Medical Disclaimer

This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.