Icosapent Ethyl
Generic Name: icosapent ethyl
Brand Names:
Icosapent Ethyl
Icosapent ethyl is a lipid-regulating agent supplied as soft gelatin capsules containing EPA ethyl ester, indicated as an adjunct to diet to reduce triglyceride levels in adult patients with severe hypertriglyceridemia.
Overview
Icosapent ethyl is a lipid-regulating agent supplied as soft gelatin capsules containing EPA ethyl ester, indicated as an adjunct to diet to reduce triglyceride levels in adult patients with severe hypertriglyceridemia.
Uses
Indicated as an adjunct to diet to reduce triglyceride levels in adult patients with severe (500 mg/dL or greater) hypertriglyceridemia.
Dosage
Daily dose is 4 grams: either four 0.5g capsules twice daily with food or two 1g capsules twice daily with food. Swallow capsules whole; do not break, crush, dissolve, or chew.
Side Effects
Common adverse reactions include musculoskeletal pain, peripheral edema, constipation, gout, and atrial fibrillation. Serious reactions include bleeding and atrial fibrillation/flutter requiring hospitalization.
Interactions
Increased bleeding risk with anticoagulants and antiplatelet agents. Monitor patients for bleeding when used concomitantly.
Warnings
Associated with increased risk of atrial fibrillation/flutter requiring hospitalization and bleeding, especially with concomitant antithrombotic medications. Contraindicated in patients with known hypersensitivity to icosapent ethyl or any components. Use caution in patients with fish allergies.
Pregnancy
Limited human data. Animal studies show non-dose-related developmental findings. Benefits must outweigh risks in pregnant women. Omega-3 fatty acids detected in breast milk.
Storage
Store at 20-25 degrees C (68-77 degrees F). Keep out of reach of children.
Frequently Asked Questions
What is Icosapent Ethyl used for?▼
Indicated as an adjunct to diet to reduce triglyceride levels in adult patients with severe (500 mg/dL or greater) hypertriglyceridemia.
What are the side effects of Icosapent Ethyl?▼
Common adverse reactions include musculoskeletal pain, peripheral edema, constipation, gout, and atrial fibrillation. Serious reactions include bleeding and atrial fibrillation/flutter requiring hospitalization.
Can I take Icosapent Ethyl during pregnancy?▼
Limited human data. Animal studies show non-dose-related developmental findings. Benefits must outweigh risks in pregnant women. Omega-3 fatty acids detected in breast milk.
What are the important warnings for Icosapent Ethyl?▼
Associated with increased risk of atrial fibrillation/flutter requiring hospitalization and bleeding, especially with concomitant antithrombotic medications. Contraindicated in patients with known hypersensitivity to icosapent ethyl or any components. Use caution in patients with fish allergies.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.