Leucovorin Calcium
Generic Name: leucovorin calcium
Brand Names:
Leucovorin Calcium
Leucovorin calcium is a water soluble reduced folate derivative used to diminish toxicity and counteract effects of impaired methotrexate elimination and inadvertent overdosages of folic acid antagonists.
Overview
Leucovorin calcium is a water soluble reduced folate derivative used to diminish toxicity and counteract effects of impaired methotrexate elimination and inadvertent overdosages of folic acid antagonists.
Uses
Diminishes toxicity and counteracts effects of impaired methotrexate elimination and inadvertent overdosages of folic acid antagonists.
Dosage
Oral tablets up to 25 mg; doses exceeding 25 mg must be given parenterally. Initial leucovorin rescue: 15 mg every 6 hours until serum methotrexate levels fall below threshold.
Side Effects
Allergic sensitization including anaphylactoid reactions and urticaria reported with oral and parenteral administration.
Interactions
Large folic acid amounts may counteract antiepileptic effects of phenobarbital, phenytoin, and primidone. High-dose leucovorin may reduce intrathecal methotrexate efficacy.
Warnings
Administer as promptly as possible after overdosage. May enhance fluorouracil toxicity with reports of severe enterocolitis and deaths in elderly patients. Improper therapy for pernicious anemia and megaloblastic anemias from vitamin B12 deficiency.
Pregnancy
Animal studies not conducted. Give to pregnant women only if clearly needed.
Frequently Asked Questions
What is Leucovorin Calcium used for?▼
Diminishes toxicity and counteracts effects of impaired methotrexate elimination and inadvertent overdosages of folic acid antagonists.
What are the side effects of Leucovorin Calcium?▼
Allergic sensitization including anaphylactoid reactions and urticaria reported with oral and parenteral administration.
Can I take Leucovorin Calcium during pregnancy?▼
Animal studies not conducted. Give to pregnant women only if clearly needed.
What are the important warnings for Leucovorin Calcium?▼
Administer as promptly as possible after overdosage. May enhance fluorouracil toxicity with reports of severe enterocolitis and deaths in elderly patients. Improper therapy for pernicious anemia and megaloblastic anemias from vitamin B12 deficiency.
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Medical Disclaimer
This drug information is for educational purposes only and should not replace professional medical advice. Drug information is sourced from the FDA National Drug Code Directory and Structured Product Labeling. Always consult with a healthcare provider before starting, stopping, or changing any medication.